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First published on July 15, 2008
A more recent version of this article appeared on January 1, 2009
Neuro Oncol 2008, DOI:10.1215/15228517-2008-050
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© Copyright 2008 by the Society for Neuro-Oncology

Received December 12, 2007
Accepted March 17, 2008

Review

Health-related quality of life in patients with high-grade glioma

Jin-xiang Cheng 1, Xiang Zhang 1*, Bo-Lin Liu 1

1 Department of Neurosurgery, Xijing Institute of Clinical Neuroscience, Xijing Hospital, Fourth Military Medical University, China


  Abstract

Health-related quality of life (HRQOL) has become an increasingly important endpoint in cancer studies; however, the research into the HRQOL of patients with high-grade glioma (HGG) is sparse, compared with that for patients with other neoplasms. Owing to the specific location and poor prognosis, it is more important and difficult to study HRQOL in patients with HGG than in those with other tumors; furthermore, the study of HRQOL in patients with HGG differs from that for patients with other tumors. In this review, we identified and compared the most frequently used instruments to assess HRQOL; analyzed specific facets and determinants of HRQOL (such as sex, tumor location and histological classification, depression, and cognitive function), as well as the association between HRQOL and survival; and appraised the effects of new treatments on HRQOL in patients with HGG from randomized controlled trials. Furthermore, we detected broadly existed problems and many contradictory outcomes, and gave some proper interpretation and suggestions regarding them.

Key Words: Health-related quality of life, high-grade glioma, instruments, depression, cognitive function, survival


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Copyright 2008 by Society for Neuro-Oncology