|
|
|
|
|
|
||
|
|
||||
|
|
||||
|
||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Basic and Translational Investigations |
1 Department of Neurological Surgery, the University of California, San Francisco, San Francisco, CA 94143 USA
2 Department of Neurological Surgery and Radiology, the University of California, San Francisco, San Francisco, CA 94143 USA
3 Department of Radiology, the University of California, San Francisco, San Francisco, CA 94143 USA
4 Department of Neuropathology, the University of California, San Francisco, San Francisco, CA 94143 USA
* To whom correspondence should be addressed. E-mail: limd{at}neurosurg.ucsf.edu.
 |
Abstract |
|---|
Neural stem cells with astrocyte-like characteristics exist in the human brain subventricular zone (SVZ), and these cells may give rise to glioblastoma multiforme (GBM). We therefore analyzed MRI features of GBMs in specific relation to the SVZ. We reviewed the preoperative and serial postoperative MR images of 53 patients with newly diagnosed GBM. The spatial relationship of the contrast-enhancing lesion (CEL) with the SVZ and cortex was determined preoperatively. Classification was as follows: group I, CEL contacting SVZ and infiltrating cortex; group II, CEL contacting SVZ but not involving cortex; group III, CEL not contacting SVZ but involving cortex; and group IV, CEL neither contacting SVZ nor infiltrating cortex. Patients with group I GBMs (n = 16) were most likely to have multifocal disease at diagnosis (9 patients, 56%, p = 0.001). In contrast, group IV GBMs (n = 14) were never multifocal. Group II (n = 14) and group III (n = 9) GBMs were multifocal in 11% and 29% of cases, respectively. Group I GBMs always had tumor recurrences noncontiguous with the initial lesion(s), while group IV GBM recurrences were always bordering the primary lesion. Group I GBMs may be most related to SVZ stem cells; these tumors were in intimate contact with the SVZ, were most likely to be multifocal at diagnosis, and recurred at great distances to the initial lesion(s). In contrast, group IV GBMs were always solitary lesions; these may arise from non-SVZ, white matter glial progenitors. Our MRI-based classification of GBMs may further our understanding of GBM histogenesis and help predict tumor recurrence pattern.
Key Words: glioblastoma multiforme (GBM), MRI, neural stem cell, subventricular zone (SVZ), tumor stem cell
CiteULike 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  T. W. Abel, C. Clark, B. Bierie, A. Chytil, M. Aakre, A. Gorska, and H. L. Moses GFAP-Cre-Mediated Activation of Oncogenic K-ras Results in Expansion of the Subventricular Zone and Infiltrating Glioma Mol. Cancer Res., May 1, 2009; 7(5): 645 - 653. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. M. Howard, Zhicheng Mo, R. Filipovic, A. R. Moore, S. D. Antic, and N. Zecevic Radial Glia Cells in the Developing Human Brain Neuroscientist, October 1, 2008; 14(5): 459 - 473. [Abstract] [PDF]
|
|
|
|
 |
|
 C. Beadle, M. C. Assanah, P. Monzo, R. Vallee, S. S. Rosenfeld, and P. Canoll The Role of Myosin II in Glioma Invasion of the Brain Mol. Biol. Cell, August 1, 2008; 19(8): 3357 - 3368. [Abstract] [Full Text] [PDF]
|
|
|
|
