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Case Study |
1 Division of Medical Oncology, Department of Medicine, Yale University School of Medicine, New Haven, CT 06510
2 Division of Hematology and Oncology, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114 and Harvard Medical School, Boston, MA 02115
3 Pappas Center for Neuro-Oncology, Massachusetts General Hospital, Boston, MA 02114
4 Departments of Neurology and Neurosurgery, Yale University School of Medicine, New Haven, CT 06510
5 Pappas Center for Neuro-Oncology, Massachusetts General Hospital, Boston, MA 02114 and Harvard Medical School, Boston, MA 02115
* To whom correspondence should be addressed. E-mail: henson{at}helix.mgh.harvard.edu.
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Abstract |
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The emergence of temozolomide as an effective alkylating agent with little acute toxicity or cumulative myelosuppression has led to protracted courses of chemotherapy for many patients with gliomas. Secondary, or treatment-related, myelodysplasia (t-MDS) and acute myelogenous leukemia (t-AML) are life-threatening complications of alkylating chemotherapy and have been reported in patients with primary brain tumors. We describe a case of temozolomide-related t-MDS/AML and discuss the clinical features of this condition. Administration of an alkylating agent in patient populations with long median survivals must be undertaken with an understanding of the potential for this treatment complication.
Key Words: brain neoplasm, glioblastoma, myelodysplastic syndrome, recurrent glioma, secondary leukemia, secondary myelodysplastic syndrome, temozolomide, treatment complication
This article has been cited by other articles:
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  B. Neyns, S. Cordera, E. Joosens, and P. Nader Non-Hodgkin's Lymphoma in Patients With Glioma Treated With Temozolomide J. Clin. Oncol., September 20, 2008; 26(27): 4518 - 4519. [Full Text] [PDF]
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