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This Article Full Text Full Text (PDF) All Versions of this Article: 11/4/452    most recent 15228517-2008-101v2 15228517-2008-101v1 Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Park, D. M. Articles by Mintz, A. Search for Related Content PubMed PubMed Citation Social Bookmarking                   What's this?

Identifying Muir-Torre syndrome in a patient with glioblastoma multiforme

Department of Neurological Surgery (A.M.), University of Pittsburgh Cancer Institute (D.M.P., J.M., N.U., L.A., J.F., F.L., A.M.), Department of Pathology (G.A.Y., R.L.H.), University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

Address correspondence to Deric M. Park, University of Pittsburgh Cancer Institute, UPMC Cancer Pavilion, 5th floor, 5150 Centre Ave., Pittsburgh, PA 15232, USA (parkdm{at}upmc.edu).

Patients with Muir-Torre syndrome, an autosomal-dominant familial tumor condition caused by germline mutation of the DNA mismatch repair genes, MSH2 or MLH1, present with tumors of the sebaceous gland and visceral malignancies characterized by microsatellite instability. Here we show development of glioblastoma multiforme in a patient with Muir-Torre syndrome. Immunohistochemical analysis of the brain tumor and colon cancer revealed loss of the DNA mismatch repair gene detected by the genetic test, suggesting a pathogenic link.

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