QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:
Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text Full Text (PDF) All Versions of this Article: 10/4/553    most recent 15228517-2008-026v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Web of Science (1) Citing Articles via Google Scholar Google Scholar Articles by Lönn, S. Articles by Inskip, P. D. Search for Related Content PubMed PubMed Citation Social Bookmarking                   What's this?

Genetic variation in insulin-like growth factors and brain tumor risk

Division of Cancer Epidemiology and Genetics (S.L., N.R., P.D.I.) and Neuro-oncology Branch (H.A.F.), National Cancer Institute, Bethesda, MD; Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ (W.R.S.); Western Pennsylvania Hospital, Pittsburgh, PA (R.G.S.); Brigham and Women's Hospital, Boston, MA (P.M.B.); Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA (J.S.L.); Division of Cancer Epidemiology and Genetics, Core Genotyping Facility, Advanced Technology Center, SAIC-Frederick, Inc., National Cancer Institute-Frederick, Frederick, MD (A.A.H.); USA

Address all correspondence to Stefan Lönn, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Room 7053, 6120 Executive Blvd., Bethesda, MD 20892-7238, USA (Stefan.Lonn{at}ki.se).

Many studies support a role for insulin-like growth factors (IGFs) in the regulation of tumor cell biology. We hypothesized that single-nucleotide polymorphisms (SNPs) in IGF genes are risk factors for glioma and meningioma. To test the hypothesis, we examined associations of brain tumor risk with nine variants in five IGF genes in a hospital-based case-control study. The study was conducted at hospitals in Boston, Phoenix, and Pittsburgh between 1994 and 1998. Eligible cases were individuals (18 years or older) newly diagnosed with glioma or meningioma. Controls were selected among patients who were admitted to the same hospitals for a variety of nonmalignant conditions and frequency matched to cases by hospital, age, sex, race, and distance from residence. The present analysis was restricted to non-Hispanic whites. DNA was extracted from blood samples collected from 354 glioma cases, 133 meningioma cases, and 495 control individuals. We evaluated nine SNPs in five IGF genes (IGF1, IGF1R, IGF2, IGF2R, and IGFBP3). The majority of the analyzed IGF SNPs did not display statistically significant associations with glioma or meningioma. For glioma, one IGF1R SNP (rs2272037) indicated a possible association. No indications of association were seen for glioblastoma, but for low-grade gliomas, the odds ratio under a dominant model was 0.56 (95% confidence interval [CI], 0.35-0.90) for IGF1 rs6220, 2.98 (95% CI, 1.65-5.38) for IGF1R rs2272037, and 1.60 (95% CI, 0.90-2.83) for IGF1R rs2016347. Overall, our results do not provide strong evidence of associations of brain tumor risk with IGF polymorphic variants but identify several associations for glioma that warrant further examination in other, larger studies.

Key Words: central nervous system • glioma • insulin-like growth factor • meningioma • single nucleotide polymorphism

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?