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First published on April 10, 2008
This version was published on January 1, 2008
Neuro Oncol 2008 10(3):236-243; DOI:10.1215/15228517-2008-006
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Rapid Report

GRP78 is overexpressed in glioblastomas and regulates glioma cell growth and apoptosis

Hae Kyung Lee, Cunli Xiang, Simona Cazacu, Susan Finniss, Gila Kazimirsky, Nancy Lemke, Norman L. Lehman, Sandra A. Rempel, Tom Mikkelsen and Chaya Brodie

Department of Neurosurgery and Hermelin Brain Tumor Center, Henry Ford Health System, Detroit, MI, USA

Address correspondence to Chaya Brodie, Hermelin Brain Tumor Center, Henry Ford Health System, 2799 W. Grand Blvd., Detroit, MI 48202, USA (nscha{at}neuro.hfh.edu).

We characterized the expression and function of the endoplasmic reticulum protein GRP78 in glial tumors. GRP78 is highly expressed in glioblastomas but not in oligodendrogliomas, and its expression is inversely correlated with median patient survival. Overexpression of GRP78 in glioma cells decreases caspase 7 activation and renders the cells resistant to etoposide- and cisplatin-induced apoptosis, whereas silencing of GRP78 decreases cell growth and sensitizes glioma cells to etoposide, cisplatin, and {gamma}-radiation. Thus, GRP78 contributes to the increased apoptosis resistance and growth of glioma cells and may provide a target for enhancing the therapeutic responsiveness of these tumors.

Key Words: apoptosis • caspase 7 • glioblastoma • GRP78 • survival


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[Abstract] [Full Text] [PDF]


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Copyright 2008 by Society for Neuro-Oncology