Home Duke University Press
QUICK SEARCH:   [advanced]


     
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

First published on April 10, 2008
This version was published on January 1, 2008
Neuro Oncol 2008 10(3):236-243; DOI:10.1215/15228517-2008-006
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
10/3/236    most recent
15228517-2008-006v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lee, H. K.
Right arrow Articles by Brodie, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Duke University Press

Rapid Report

GRP78 is overexpressed in glioblastomas and regulates glioma cell growth and apoptosis

Hae Kyung Lee, Cunli Xiang, Simona Cazacu, Susan Finniss, Gila Kazimirsky, Nancy Lemke, Norman L. Lehman, Sandra A. Rempel, Tom Mikkelsen and Chaya Brodie

Department of Neurosurgery and Hermelin Brain Tumor Center, Henry Ford Health System, Detroit, MI, USA

Address correspondence to Chaya Brodie, Hermelin Brain Tumor Center, Henry Ford Health System, 2799 W. Grand Blvd., Detroit, MI 48202, USA (nscha{at}neuro.hfh.edu).

We characterized the expression and function of the endoplasmic reticulum protein GRP78 in glial tumors. GRP78 is highly expressed in glioblastomas but not in oligodendrogliomas, and its expression is inversely correlated with median patient survival. Overexpression of GRP78 in glioma cells decreases caspase 7 activation and renders the cells resistant to etoposide- and cisplatin-induced apoptosis, whereas silencing of GRP78 decreases cell growth and sensitizes glioma cells to etoposide, cisplatin, and {gamma}-radiation. Thus, GRP78 contributes to the increased apoptosis resistance and growth of glioma cells and may provide a target for enhancing the therapeutic responsiveness of these tumors.

Key Words: apoptosis • caspase 7 • glioblastoma • GRP78 • survival






  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents


Copyright 2008 by Society for Neuro-Oncology