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Retrospective Clinical Studies |
Departments of Radiation Oncology (D.R., F.F., W.A.), Neurosurgery (K.L., M.W.), and Neuropathology (C.H.), University Hospital Hamburg-Eppendorf, Hamburg, Germany; Department of Radiation Oncology, Mayo Clinic Scottsdale, Scottsdale, AZ 85259 (S.E.S.), USA
1 Address correspondence to Dirk Rades, Department of Radiation Oncology, University Hospital Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany (Rades.Dirk{at}gmx.net).
Abstract
Most neurocytomas are well differentiated, being associated with better
long-term survival than the more aggressive atypical lesions. Atypical
neurocytomas are characterized by an MIB-1 labeling index >3% or atyp-ical
histologic features. This analysis focuses on well-differentiated neurocytomas
in order to define the optimal treatment. A case with a follow-up of 132
months is presented. The patient developed two recurrences two and four years
after first surgery, each showing an increasing proliferation activity.
Furthermore, all published well-differentiated neurocytoma cases were reviewed
for surgery, radiotherapy, and prognosis. Additional rel-evant data were
obtained from the authors. Complete resection (CTR), complete resection plus
radiotherapy (CTR + RT), incomplete resection (ITR), and incomplete resection
plus radiotherapy (ITR + RT) were compared for outcome by using the
Kaplan-Meier method and the log-rank test. Data were complete in 301 patients
(CTR, 108; CTR + RT, 27; ITR, 81; ITR + RT, 85). Local control and survival
were better after CTR than after ITR (P < 0.0001 and P =
0.0085, respectively). Radiotherapy improved local control after ITR
(P < 0.0001) and after CTR (P = 0.0474), but not survival
(P = 0.17 and P = 1.0, respectively). In the ITR + RT group,
doses 
54 Gy (n = 33) and >54 Gy (n = 32) were not significantly
different for local control (P = 0.88) and survival (P =
0.95). The data demonstrated CTR to be superior to ITR for local control and
survival. After CTR and ITR, radiotherapy improved local control, but not
survival. A radiation dose of 54 Gy appeared sufficient. Application of
postoperative radiotherapy should be decided individually, taking into account
the risk of local failure, the need for another craniotomy, and potential
radiation toxicity.
References
Ashkan, K., Casey, A.T., D'Arrigo, C., Harkness, W.F., and Thomas, D.G. (2000) Benign central neurocytoma. Cancer 89,1111 -1120.[CrossRef][Web of Science][Medline]
Bolen, J.W., Jr., Lipper, M.H., and Caccamo, D. (1989) Intraventricular central neurocytoma: CT and MR findings. J. Comput. Assist. Tomogr. 13,495 -497.[Web of Science][Medline]
Brat, D.J., Scheithauer, B.W., Eberhart, C.G., and Burger, P.C. (2001) Extraventricular neurocytomas: Pathologic features and clinical outcome. Am. J. Surg. Pathol. 25,1252 -1260.[CrossRef][Web of Science][Medline]
Brown, D.M., Karlovits, S., Lee, L.H., Kim, K., Rothfus, W.E., and Brown, H.G. (2001) Management of neurocytomas: Case report and review of the literature. Am. J. Clin. Oncol. 24,272 -278.[CrossRef][Web of Science][Medline]
Chang, K.H., Han, M.H., Kim, D.G., Chi, J.G., Suh, D.C., Kim, S.J., Cha, S.H., and Han, M.C. (1993) MR appearance of central neurocytoma. Acta Radiol. 34,520 -526.[Web of Science][Medline]
Cobery, S.T., Noren, G., Friehs, G.M., Chougule, P., Zheng, Z., Epstein, M.H., and Taylor, W. (2001) Gamma knife surgery for treatment of central neurocytomas. J. Neurosurg. 94,327 -330.[Web of Science][Medline]
Coca, S., Moreno, M., Martos, J.A., Rodriguez, J., Barcena, A., and Vaquero, J. (1994) Neurocytoma of spinal cord. Acta Neuropathol. 87,537 -540.[Medline]
Elek, G., Slowik, F., Eross, L., Toth, S., Szabo, Z., and Balint, K. (1999) Central neurocytoma with malignant course. Neuronal and glial differentiation and craniospinal dissemination. Pathol. Oncol. Res. 5,155 -159.[CrossRef][Medline]
Enam, S.A., Rosenblum, M.L., and Ho, K.L. (1997) Neurocytoma in the cerebellum. Case report. J. Neurosurg. 87,100 -102.[Web of Science][Medline]
Eng, D.Y., DeMonte, F., Ginsberg, L., Fuller, G.N., and Jaeckle, K. (1997) Craniospinal dissemination of central neurocytoma. Report of two cases. J. Neurosurg. 86,547 -552.[CrossRef][Web of Science][Medline]
Favereaux, A., Vital, A., Loiseau, H., Dousset, V., Caille, J., and Petry, K. (2000) Histopathological variants of central neurocytoma: Report of 10 cases. Ann. Pathol. 20,558 -563.[Web of Science][Medline]
Hanel, R.A, Montano, J.C., Gasparetto, E., Ditzel, L.F., Torres, L.F., and Araujo, J.C. (2001) Uncommon presentation of central neurocytoma causing intraventricular hemorrhage: Case report. Arq. Neuropsiquiatr. 59,628 -632.[Medline]
Hassoun, J., Gambarelli, D., Grisoli, F., Pellet, W., Salamon, G., Pellissier, J.F., and Toga, M. (1982) Central neurocytoma. An electron-microscopic study of two cases. Acta Neuropathol. 56,151 -156.[CrossRef][Medline]
Hassoun, J., Soylemezoglu, F., Gamberelli, D., Figarella-Branger, D., von Ammon, K., and Kleihues, P. (1993) Central neurocytoma: A synopsis of clinical and histological features. Brain Pathol. 3,297 -306.[Web of Science][Medline]
Hessler, R.B., Lopes, M.B., Frankfurter, A., Reidy, J., and VandenBerg, S.R. (1992) Cytoskeletal immunohistochemistry of central neurocytomas. Am. J. Surg. Pathol. 16,1031 -1038.[CrossRef][Web of Science][Medline]
Ishiuchi, S., and Tamura, M. (1997) Central neurocytoma: An immunohistochemical, ultrastructural and cell culture study. Acta Neuropathol. 94,425 -435.[CrossRef][Medline]
Jamshidi, J., Izumoto, S., Yoshimine, T., and Maruno, M. (2001) Central neurocytoma presenting with intratumoral hemorrhage. Neurosurg. Rev. 24, 48-52.[CrossRef][Web of Science][Medline]
Kim, C.Y., Paek, S.H., and Kim, D.G. (2003) Linear accelerator radiosurgery for central neurocytoma: A case report. J. Neurooncol. 61,249 -254.[CrossRef][Medline]
Kim, D.G., Chi, J.G., Park, S.H., Chang, K.H., Lee, S.H., Jung, H.W., Kim, H.J., Cho, B.K., Choi, K.S., and Han, D.H. (1992) Intraventricular neurocytoma: Clinicopathological analysis of seven cases. J. Neurosurg. 76,759 -765.[Web of Science][Medline]
Kubota, T., Hayashi, M., Kawano, H., Kabuto, M., Sato, K., Ishise, J., Kawamoto, K., Shirataki, K., Iizuka, H., Tsunoda, S., and Katsuyama, J. (1991) Central neurocytoma: Immunohistochemical and ultrastructural study. Acta Neuropathol. 81,418 -427.[CrossRef][Medline]
Louis, D.N., Swearingen, B., Linggood, R.M., Dickersin, G.R., Kretschmar, C., Bhan, A.K., and Hedley-Whyte, E.T. (1990) Central nervous system neurocytoma and neuroblastoma in adults—report of eight cases. J. Neurooncol. 9,231 -238.[CrossRef][Medline]
Mackenzie, I.R. (1999) Central neurocytoma: Histologic atypia, proliferation potential, and clinical outcome. Cancer 85,1606 -1610.[CrossRef][Web of Science][Medline]
Majos, C., Coll, S., and Pons, L.C. (1997) Central neurocytoma arising in the third ventricle. Neuroradiologyy 39,270 -272.[CrossRef]
Metellus, P., Dufour, H., Fuentes, S., Do, L., Figarella-Branger, G., and Grisoli, F. (2001) [Central neurocytoma revealed by intraventricular hemorrhage. A case report and review of the literature.] Neurochirur gie 47,445 -447.
Namiki, J., Nakatsukasa, M., Murase, I., and Yamazaki, K. (1998) Central neurocytoma presenting with intratumoral hemorrhage 15 years after initial treatment by partial removal and irradiation. Neurol. Med. Chir. 38,278 -282.
Oken, M.M., Creech, R.H., Tormey, D.C., Horton, J., Davis, T.E., McFadden, E.T., and Carbone, P.P. (1982) Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am. J. Clin. Oncol. 5,649 -655.[Web of Science][Medline]
Preston-Martin, S. (2003) Epidemiology of primary brain tumors. In: Petrovich, Z., Brady, L.W., Apuzzo, M.L., and Bamberg, M. (Eds.), Combined Modality Therapy of Central Nervous System Tumors. Berlin-Heidelberg-New York: Springer, pp.1 -17.
Rades, D., Schild, S.E., and Fehlauer, F. (2004a) The
prognostic value of the MIB-1 labeling index for central neurocytomas.
Neurology 62,987
-989.
Rades, D., Fehlauer, F., and Schild, S.E. (2004b) Treatment of atypical neurocytomas. Cancerr 100,814 -817.[CrossRef]
Salvati, M., Cervoni, L., Caruso, R., and Gagliardi, F.M. (1997) Central neurocytoma: Clinical features of 8 cases. Neurosurg. Rev. 20,39 -43.[CrossRef][Web of Science][Medline]
Sgouros, S., Carey, M., Aluwihare, N., Barber, P., and Jackowski, A. (1998) Central neurocytoma: A correlative clinicopathologic and radiologic analysis. Surg. Neurol. 49,197 -204.[CrossRef][Web of Science][Medline]
Smoker, W., Townsend, J.J., and Reichman, M.V. (1991) Neurocytoma accompanied by intraventricular hemorrhage: Case report and literature review. AJNR Am. J. Neuroradiol. 12,765 -770.[Web of Science][Medline]
Stapleton, S.R., David, K.M., Harkness, W.F., and Harding, B.N.
(1997) Central neurocytoma of the cervical spinal cord.
J. Neurol. Neurosurg. Psychiatry
63, 119
(letter).
Stephan, C.L., Kepes, J.J., Arnold, P., Green, K.D., and Chamberlin, F. (1999) Neurocytoma of the cauda equina. Case report. J. Neurosurg. Spine 90,247 -251.
Tacconi, L., Thom, M., and Symon, L. (1997) Central neurocytoma: A clinicopathological study of five cases. Br. J. Neurosurg. 11,286 -291.[CrossRef][Web of Science][Medline]
Tatter, S.B., Borges, L.F., and Louis, D.N. (1994) Central neurocytomas of the cervical spinal cord. Report of two cases. J. Neurosurg. 81,288 -293.[Web of Science][Medline]
Taylor, C.L., Cohen, M.L., and Cohen, A.R. (1998) Neurocytoma presenting with intraparenchymal cerebral hemorrhage. Pediatr. Neurosurg. 29,92 -95.[CrossRef][Web of Science][Medline]
Tomura, N., Hirano, H., Watanabe, O., Watarai, J., Itoh, Y., Mineura, K., and Kowada, M. (1997) Central neurocytoma with clinically malignant behavior. Am. J. Neuroradiol. 18,1175 -1178.[Abstract]
Tsuchida, T., Matsumoto, M., Shirayama, Y., Imahori, T., Kasai, H., and Kawamoto, K. (1996) Neuronal and glial characteristics of central neurocytoma: Electron microscopical analysis of two cases. Acta Neuro pathol. 91,573 -577.
Tyler-Kabara, E., Kondziolka, D., Flickinger, J.C., and Lunsford, L.D. (2001) Stereotactic radiosurgery for residual neurocytoma. Report of four cases. J. Neurosurg. 95,879 -882.[CrossRef][Web of Science][Medline]
Uematsu, Y., Tanakla, Y., Shimizu, M., Oobayashi, S., Fujita, K., Nakai, K., Itakura, T., Moriwaki, H., and Kamei, I. (2001) Histogenesis and proliferative activity of central neurocytomas. Brain Tumor Pathol. 18,29 -36.[CrossRef][Medline]
Vates, G.E., Arthur, K.A., Ojemann, S.G., Williams, F., and Lawton, M.T. (2001) A neurocytoma and an associated lenticulostriate artery aneurysm presenting with intraventricular hemorrhage: Case report. Neurosurgery 49,721 -725.[CrossRef][Web of Science][Medline]
von Deimling, A., Janzer, R., Kleihues, P., and Wiestler, O.D. (1990) Patterns of differentiation in central neurocytoma. An immunohistochemical study of eleven biopsies. Acta Neuropathol. 79,473 -479.[CrossRef][Medline]
Westphal, M., Meissner, H., Matschke, J., and Herrmann, H.D. (1998) Tissue culture of human neurocytomas induces the expression of glial fibrillary acidic protein. J. Neurocytol. 27,805 -816.[CrossRef][Web of Science][Medline]
Wichmann, W., Schubiger, O., von Deimling, A., Schenker, C., and Valavanis, A. (1991) Neuroradiology of central neurocytoma. Neuroradiology 33,143 -148.[CrossRef][Web of Science][Medline]
Yamamoto, T., Komori, T., Shibata, N., Toyoda, C., and Kobayashi, M. (1996) Multifocal neurocytoma/gangliocytoma with extensive leptomeningeal dissemination in the brain and spinal cord. Am. J. Surg. Pathol. 20,363 -370.[CrossRef][Web of Science][Medline]
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