|
|
|
|
|
|
||
|
|
||||
|
|
||||
|
||||
Epidemiology and Cancer Control |
Division of Cancer Epidemiology and Genetics (D.A.H., M.S.L., P.D.I.) and Neuro-Oncology Branch (H.A.F.), National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892; Department of Neurosurgery, Brigham and Women's Hospital, Boston, MA 02115 (P.M.B.); Division of Neurosurgery, Western Pennsylvania Hospital, Pittsburgh, PA 15224 (R.G.S.); and Department of Neurology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ 85013 (W.R.S.); USA
1 Address correspondence to Deirdre A. Hill, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, MSC 7238 N, Bethesda, MD 20892-7238 (dhill{at}mail.nih.gov).
Abstract
Relatively little is known about factors that contribute to the development of meningioma and vestibular schwannoma, two intracranial nervous system tumors. We evaluated the risk of these tumors in relation to family history of malignant or benign tumors. Incident cases of meningioma (n = 197) or schwannoma (n = 96) were identified at three U.S. referral hospitals between June 1994 and August 1998. Controls (n = 799) admitted to the same hospitals for nonmalignant conditions were matched to cases on age, sex, race/ethnicity, hospital, and proximity of residence to hospital. We found that risk of meningioma was increased among persons reporting a family history of a benign brain tumor (odds ratio [OR], 4.5; 95% confidence interval [CI], 1.0–21.0; n = 5) or melanoma (OR, 4.2; 95% CI, 1.2–15.0; n = 5). A family history of breast cancer was associated with an elevated meningioma risk among participants aged 18 to 49 years (OR, 3.9; 95% CI, 1.4–11.0; n = 8) but a reduced risk among older respondents (OR, 0.2; 95% CI, 0.1–0.7; n = 3). Family history of cancer did not differ between schwannoma cases and controls, although the statistical power to detect associations was limited. Some relative risk estimates were based on a small number of observations and may have arisen by chance. Inheritance of predisposing genes, shared environmental factors, or both within families with a history of benign brain tumors, melanoma, or possibly breast cancer may be related to altered meningioma risk.
References
Aarnio, M., Sankila, R., Pukkala, E., Salovaara, R., Aaltonen, L.A., de la Chapelle, A., Peltomaki, P., Mecklin, J.P., and Jarvinen, H.J. (1999) Cancer risk in mutation carriers of DNA-mismatch-repair genes. Int. J. Cancer 81,214 -218.[CrossRef][ISI][Medline]
Adami, H.O., Bergkvist, L., Krusemo, U., and Persson, I. (1984) Breast cancer as a risk factor for other primary malignant diseases. A nationwide cohort study. J. Natl. Cancer Inst. 73,1049 -1055.
Airewele, G., Adatto, P., Cunningham, J., Mastromarino, C.,
Spencer, C., Sharp, M., Sigurdson, A., and Bondy, M. (1998)
Family history of cancer in patients with glioma: A validation study of
accuracy. J. Natl. Cancer Inst.
90,543
-544.
Bahuau, M., Vidaud, D., Jenkins, R.B., Bieche, I., Kimmel, D.W.,
Assouline, B., Smith, J.S., Alderete, B., Cayuela, J.M., Harpey, J.P., Caille,
B., and Vidaud, M. (1998) Germ-line deletion involving the INK4
locus in familial proneness to melanoma and nervous system tumors.
Cancer Res. 58,2298
-2303.
Bostrom, J., Meyer-Puttlitz, B., Wolter, M., Blaschke, B., Weber,
R.G., Lichter, P., Ichimura, K., Collins, V.P., and Reifenberger, G.
(2001) Alterations of the tumor suppressor genes CDKN2A
(p16(INK4a)), p14(ARF), CDKN2B (p15(INK4b)), and CDKN2C
(p18(INK4c)) in atypical and anaplastic meningiomas. Am. J.
Pathol. 159,661
-669.
Choi, N.W., Schuman, L.M., and Gullen, W.H. (1970)
Epidemiology of primary central nervous system neoplasms. II. Case-control
study. Am. J. Epidemiol.
91,467
-485.
Custer, B.S., Koepsell, T.D., and Mueller, B.A. (2002) The association between breast carcinoma and meningioma in women. Cancer 94,1626 -1635.[CrossRef][ISI][Medline]
Goto, M., Miller, R.W., Ishikawa, Y., and Sugano H. (1996) Excess of rare cancers in Werner Syndrome (Adult progeria). Cancer Epidemiol. Biomarkers Prev. 5, 239-246.[Abstract]
Harner, S.G., and Laws, E.R., Jr. (1981) Diagnosis of acoustic neurinoma. Neurosurgery 9, 373-379.[ISI][Medline]
Helseth, A., Mork, S.J., and Glattre, E. (1989) Neoplasms of the central nervous system in Norway. V. Meningioma and cancer of other sites. An analysis of the occurrence of multiple primary neoplasms in meningioma patients in Norway from 1955 through 1986. APMIS 97,738 -744.[ISI][Medline]
Hemminki, K., Li, X., and Collins, V.P. (2001a) Parental cancer as a risk factor for brain tumors (Sweden). Cancer Causes Control 12,195 -199.[CrossRef][ISI][Medline]
Hemminki, K., Lonnstedt, I., and Vaittinen, P. (2001b) A population-based study of familial cutaneous melanoma. Melanoma Res. 11,133 -140.[CrossRef][ISI][Medline]
Hill, D.A., Inskip, P.D., Shapiro, W.R., Selker, R.G., Fine, H.A.,
Black, P.M., and Linet, M.S. (2003) Cancer in first-degree
relatives and risk of glioma in adults. Cancer Epidemiol.
Biomarkers Prev. 12,1443
-1448.
Inskip, P.D., Hatch, E.E., Stewart, P.A., Heineman, E.F., Ziegler, R.G., Dosemeci, M., Parry, D., Rothman, N., Boice, J.D., Wilcosky, T.C., Watson, D.J., Shapiro, W.R., Selker, R.G., Fine, H.A., Black, P.M., Loeffler, J.S., and Linet, M.S. (1999) Study design for a case-control investigation of cellular telephones and other risk factors for brain tumours in adults. Radiat. Prot. Dosimetry 86, 45-52.[Abstract]
Inskip, P.D., Tarone, R.E., Hatch, E.E., Wilcosky, T.C., Fine,
H.A., Black, P.M., Loeffler, J.S., Shapiro, W.R., Selker, R.G., and Linet,
M.S. (2003) Sociodemographic indicators and risk of brain tumors.
Int. J. Epidemiol. 32,225
-233.
Kirsch, M., Zhu, J.J., and Black, P.M. (1997) Analysis of the BRCA1 and BRCA2 genes in sporadic meningiomas. Genes Chromosomes Cancer 20, 53-59.[CrossRef][ISI][Medline]
Khoury, M.J., and Flanders, W.D. (1995) Bias in using family history as a risk factor in case-control studies of disease. Epidemiology 6,511 -519.[ISI][Medline]
Malmer, B., Tavelin, B., Henriksson, R., and Gronberg, H. (2000) Primary brain tumours as second primary: A novel association between meningioma and colorectal cancer. Int. J. Cancer 85,78 -81.[CrossRef][ISI][Medline]
Malmer, B., Henriksson, R., and Gronberg, H. (2003). Familial brain tumours—genetics or environment? A nationwide cohort study of cancer risk in spouses and first-degree relatives of brain tumour patients. Int. J. Cancer 106,260 -263.[CrossRef][ISI][Medline]
McCarthy, B.J., Davis, F.G., Freels, S., Surawicz, T.S., Damek, D.M., Grutsch, J., Menck, H.R., and Laws, E.R., Jr. (1998) Factors associated with survival in patients with meningioma. J. Neurosurg. 88,831 -839.[ISI][Medline]
Mirimanoff, R.O., Dosoretz, D.E., Linggood, R.M., Ojemann, R.G., and Martuza, R.L. (1985) Meningioma: Analysis of recurrence and progression following neurosurgical resection. J. Neurosurg. 62,18 -24.[ISI][Medline]
Paunu, N., Pukkala, E., Laippala, P., Sankila, R., Isola J., Miettinen, H., Simola, K.O., Helen, P., Helin, H., and Haapasalo, H. (2002) Cancer incidence in families with multiple glioma patients. Int. J. Cancer 97,819 -822.[CrossRef][ISI][Medline]
Percy, C., Van Holten, V., and Muir, C., Eds. (1990)International Classification of Diseases for Oncology, 2nd ed. Geneva: World Health Organization, 1990.
Preston, D.L., Ron, E., Yonehara, S., Kobuke, T., Fujii, H.,
Kishikawa, M., Tokunaga, M., Tokuoka, S., and Mabuchi, K. (2002)
Tumors of the nervous system and pituitary gland associated with atomic bomb
radiation exposure. J. Natl. Cancer Inst.
94,1555
-1563.
Preston-Martin, S. (1989) Descriptive epidemiology of primary tumors of the brain, cranial nerves and cranial meninges in Los Angeles County. Neuroepidemiology 8, 283-295.[CrossRef][ISI][Medline]
Preston-Martin, S., Paganini-Hill, A., Henderson, B.E., Pike, M.C., and Wood, C. (1980) Case-control study of intracranial meningiomas in women in Los Angeles County, California. J. Natl. Cancer Inst. 65,67 -73.
Preston-Martin, S., Mack, W., and Henderson, B.E.
(1989) Risk factors for gliomas and meningiomas in males in Los
Angeles County. Cancer Res.
49,6137
-6143.
Randerson-Moor, J.A., Harland, M., Williams, S., Cuthbert-Heavens,
D., Sheridan, E., Aveyard, J., Sibley, K., Whitaker, L., Knowles, M., Bishop,
J.N., and Bishop, D.T. (2001) A germline deletion of
p14(ARF) but not CDKN2A in a melanoma-neural system tumour
syndrome family. Hum. Mol. Genet.
10, 55-62.
Ron, E., Modan, B., Boice, J.D., Jr., Alfandary, E., Stovall, M., Chetrit, A., and Katz, L. (1988) Tumors of the brain and nervous system after radiotherapy in childhood. N. Engl. J. Med. 319,1033 -1039.[Abstract]
Ryan, P., Lee, M.W., North, B., and McMichael, A.J. (1992) Risk factors for tumors of the brain and meninges: Results from the Adelaide Adult Brain Tumor Study. Int. J. Cancer 51,20 -27.[ISI][Medline]
Schoenberg, B.S., Christine, B.W., and Whisnant, J.P.
(1975) Nervous system neoplasms and primary malignancies of other
sites. The unique association between meningiomas and breast cancer.
Neurology 25,705
-712.
Weber, R.G., Bostrom, J., Wolter, M., Baudis, M., Collins, V.P.,
Reifenberger, G., and Lichter, P. (1997) Analysis of genomic
alterations in benign, atypical, and anaplastic meningiomas: Toward a genetic
model of meningioma progression. Proc. Natl. Acad. Sci.
USA 94,14719
-14724.
Weinberg, C.R., Moledor, E.S., Umbach, D.M., and Sandler, D.P. (1996) Imputation for exposure histories with gaps, under an excess relative risk model. Epidemiology 7, 490-497.[ISI][Medline]
Wertelecki, W., Rouleau, G.A., Superneau, D.W., Forehand, L.W., Williams, J.P., Haines, J.L., and Gusella, J.F. (1988) Neurofibromatosis 2: Clinical and DNA linkage studies of a large kindred. N. Engl. J. Med. 319,278 -283.[Abstract]
Wrensch, M., Lee, M., Miike, R., Newman, B., Barger, G., Davis, R.,
Wiencke, J., and Neuhaus, J. (1997) Familial and personal medical
history of cancer and nervous system conditions among adults with glioma and
controls. Am. J. Epidemiol.
145,581
-593.
Young, D.F., Eldridge, R., and Gardner, W.J. (1970) Bilateral acoustic neuroma in a large kindred. JAMA 214,347 -353.[CrossRef][Medline]
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|
