|
|
|
|
|
|
||
|
|
||||
|
|
||||
|
||||
Case Study |
Department of Oncology (M.Y.A., S.A.G.); Department of Surgery, Division of Thoracic Surgery (S.C.Y.); Department of Pathology (P.C.B.); and Department of Medicine, Division of Pulmonary and Critical Care (J.B.O.), Johns Hopkins Medical Institutions, Baltimore, MD 21231; University of Maryland School of Medicine, Baltimore, MD 21201 (B.W.); and Washington University School of Medicine, St. Louis, MO 63110 (A.P.); USA
1 Address correspondence to Mary Y. Armanios, Department of Oncology, Johns Hopkins Medical Institutions, 1650 Orleans Street, Cancer Research Building, Room 86, Baltimore, MD 21231 (marmani1{at}jhmi.edu).
Abstract
Donor-acquired solid organ malignancy is a rare complication of organ transplantation. We report a case of a patient who received bilateral lung transplants for pulmonary fibrosis from a donor with known glioblastoma multiforme (GBM). The lungs, heart, liver, and kidneys were harvested after a lethal intracranial bleed and accepted for transplantation by four centers. An enlarged hilar lymph node sampled at the time of transplant was found to contain GBM. Four months later, the patient developed diffuse interstitial pulmonary infiltrates with mediastinal lymphadenopathy. Lung biopsy confirmed metastatic GBM. The patient died 2 weeks after the diagnosis was established. The patient receiving the donor liver also developed GBM. We present a case study, review of the literature, and suggested interventions to minimize the risk of transmission.
References
American Cancer Society (2002) Cancer Facts & Figures 2002. Atlanta, Ga.: American Cancer Society. Cited May 10, 2003. Available at http://www.cancer.org/downloads/STT/CancerFacts&Figures2002TM.pdf.
Bosmans, J.L., Ysebaert, D., De Cock, A.M., Hauben, E., Muylle, L., Schrijvers, D., Van Marck, E., Eyskens, E., and De Broe, M.E. (1997) Interferon-alpha and the cure of metastasis of a malignant meningioma in a kidney allograft recipient: A case report. Transplant. Proc. 29,838 .[Medline]
Burger, P.C., Scheithauer, B.W., and Vogel, F.S. (2002) Surgical Pathology of the Nervous System and Its Coverings. New York: Churchill Livingstone, p.196 .
Cerame, M.A., Guthikonda, M., and Kohli, C.M. (1985) Extraneural metastases in gliosarcoma: A case report and review of the literature. Neurosurgery 17,413 -418.[Medline]
Colquhoun, S.D., Robert, M.E., Shaked, A., Rosenthal, J.T., Millis, T.M., Farmer, D.G., Jurim, O., and Busuttil, R.W. (1994) Transmission of CNS malignancy by organ transplantation. Transplantation 57,970 -974.[Medline]
Fecteau, A.H., Penn, I., and Hanto, D.W. (1998) Peritoneal metastasis of intracranial glioblastoma via a ventriculoperitoneal shunt preventing organ retrieval: Case report and review of the literature. Clin. Transplant. 12,348 -350.[Medline]
Frank, S., Muller, J., Bonk, C., Haroske, G., Schackert, H.K, and Schackert, G. (1998) Transmission of glioblastoma multiforme through liver transplantation. Lancet 352, 31.[CrossRef][ISI][Medline]
Frappaz, D., Jouvet, A., Pierre, G.S., Giammarile, F., Guyotat, J., Deruty, R., Jouanneau, E., and Ranchere-Vince, D. (2001) Lack of evidence of osteo-medullary metastases at diagnosis in patients with high grade gliomas. J. Neurooncol. 52,249 -252.[Medline]
Fuller, C.E., Schmidt, R.E., Roth, K.A., Burger, P.C., Scheithauer, B.W., Banerjee, R., Trinkaus, K., Lytle, R., and Perry, A. (2003) Clinical utility of fluorescence in situ hybridization (FISH) in morphologically ambiguous gliomas with hybrid oligodendroglial/astrocytic features. J. Neuropathol. Exp. Neurol. 62,1118 -1128.[Medline]
Jonas, S., Bechstein, W.O., Lemmens, H.P., Neuhaus, R., Thalmann, U., and Neuhaus, P. (1996) Liver graft-transmitted glioblastoma multiforme. A case report and experience with 13 multiorgan donors suffering from primary cerebral neoplasia. Transplant. Int. 9, 426-429.[Medline]
Kauffman, H.M., McBride, H.M., and Delmonico, F.L. (2000) First report of the United Network for Organ Sharing Transplant Tumor Registry: Donors with a history of cancer. Transplantation 70,1747 -1751.[CrossRef][Medline]
Kauffman, H.M., McBride, M.A., Cherikh, W.S., Spain, P.C., and Delmonico, F.L. (2002) Transplant tumor registry: Donors with central nervous system tumors. Transplantation 73,579 -582.[Medline]
Konigsrainer, A., Steurer, W., Schumer, J., Geissler, D., Mourad, M., Squifflet, J.P., and Margreiter, R. (1993) Transmission of non-Hodgkin's lymphoma through renal allografts—disastrous result of false diagnosis and inadequate information. Transplant. Proc. 25,3075 -3076.[Medline]
Lefrancois, N., Touraine, J.L., Cantarovich, D., Cantarovich, F., Faure, J.L., Dubernard, J.M., Dureau, G., Colpart, J.J., Bouvier, R., and Traeger, J. (1987) Transmission of medulloblastoma from cadaver donor to three organ transplant recipients. Transplant. Proc. 19,2242 .[ISI][Medline]
McComb, J.G., Davis, R.L., and Isaacs, H., Jr. (1981) Extraneural metastatic medulloblastoma during childhood. Neurosurgery 9,548 -551.[Medline]
Morse, J.H., Turcotte, J.G., Merion, R.M., Campbell, D.A., Jr., Burtch, G.D., and Lucey, M.R. (1990) Development of a malignant tumor in a liver transplant graft procured from a donor with a cerebral neoplasm. Transplantation 50,875 -877.[Medline]
Penn, I. (1997) Overview of the problem of cancer in organ transplant recipients. Ann. Transplant. 2, 5-6.[Medline]
Ruiz, J.C., Cotorruelo, J.G., Tudela, V., Ullate, P.G., Val-Bernal, F., de Francisco, A.L., Zubimendi, J.A., Prieto, M., Canga, E., and Arias, M. (1993) Transmission of glioblastoma multiforme to two kidney transplant recipients from the same donor in the absence of ventricular shunt. Transplantation 55,682 -683.[ISI][Medline]
UNOS. United Network for Organ Sharing (2003) OPTN.The Organ Procurement and Transplantation Network (2003) Data files . Richmond, Va.: United Network for Organ Sharing. Cited May 15, 2003. Available at www.OPTN.org
Val-Bernal, F., Ruiz, J.C., Cotorruelo, J.G., and Arias, M. (1993) Glioblastoma multiforme of donor origin after renal transplantation: Report of a case. Hum. Pathol. 24,1256 -1259.[Medline]
Weill, D. (2002) Donor criteria in lung
transplantation: An issue revisited. Chest
121,2029
-2031.
This article has been cited by other articles:
|
|
 |
|
  H. Chen, A. S. Shah, R. E. Girgis, and S. A. Grossman Transmission of Glioblastoma Multiforme After Bilateral Lung Transplantation J. Clin. Oncol., July 1, 2008; 26(19): 3284 - 3285. [Full Text] [PDF]
|
|
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|
