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Neuro Oncol 2004 6(1):33-37; DOI:10.1215/S1152851703000309
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Duke University Press

Clinical Investigations

Phase 2 study of BCNU and temozolomide for recurrent glioblastoma multiforme: North American Brain Tumor Consortium study

Michael D. Prados2, W.K. Alfred Yung, Howard A. Fine, Harry S. Greenberg, Larry Junck, Susan M. Chang, M. Kelly Nicholas, H. Ian Robins, Minesh P. Mehta, Karen L. Fink, Kurt A. Jaeckle, John Kuhn, Kenneth R. Hess and S. Clifford Schold, Jr.

Departments of Neurological Surgery (M.D.P., S.M.C.) and Neuro-Oncology (M.K.N.), University of California at San Francisco, San Francisco, CA 94143; Departments of Neuro-Oncology (W.K.A.Y.) and Biostatistics (K.R.H.), The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030; Neuro-Oncology Branch, National Cancer Institute, Bethesda, MD 20892 (H.A.F.); Department of Neurology, University of Michigan, Ann Arbor, MI 48109 (H.S.G., L.J.); Departments of Medicine (H.I.R.) and Radiotherapy (M.P.M.), University of Wisconsin, Madison, WI 53792; Department of Neurology, The University of Texas Southwestern Medical Center, Dallas, TX 75390 (K.L.F.); Departments of Neurology and Hematology/Oncology, Mayo Clinic Jacksonville, Jacksonville, FL 32224 (K.A.J.); College of Pharmacy, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 (J.K.); Office of Clinical Research, University of Pittsburgh, Pittsburgh, PA 15261 (S.C.S.); USA

2 Address correspondence to Michael Prados, University of California at San Francisco, 400 Parnassus Avenue, Room A808, San Francisco, CA 94143, USA (pradosm{at}neurosurg.ucsf.edu).

References

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Rich, J., Reardon, D., Allen, D., Affronti, M., Carter, J., Edwards, S., Friedman, A., Gururangan, S., Herndon, J., Jackson, S., McLendon, R., Quinn, J., Tourt-Uhlig, S., Sampson, J., Bigner, D., Stafford-Fox, V., Zaknoen, S., and Friedman, H. (2001) Phase I/II trial of Gliadel plus Temodar for adult patients with recurrent high-grade glioma. Proc. Am. Soc. Clin. Oncol. 20, 75b (abstract 2051).

Schold, S.C. Jr., Kuhn, J.G., Chang, S.M., Bosik, M.E., Robins, H.I., Mehta, M.P., Spence, A.M., Fulton, D., Fink, K.L., and Prados, M.D. (2000) A phase I trial of 1,3-bis(2-chloroethyl)-1-nitrosourea plus temozolomide: A North American Brain Tumor Consortium study. Neuro-Oncol. 2,34 -39.[Abstract]

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Yung, W.K., Prados, M.D., Yaya-Tur, R., Rosenfeld, S.S., Brada, M., Friedman, H.S., Albright, R., Olson, J., Chang, S.M., O'Neill, A.M., Friedman, A.H., Bruner, J., Yue, N., Dugan, M., Zaknoen, S., and Levin, V.A. (1999) Multicenter phase II trial of temozolomide in patients with anaplastic astrocytoma or anaplastic oligoastrocytoma at first relapse. Temodal Brain Tumor Group. J. Clin. Oncol. 17,2762 -2771.[Abstract/Free Full Text]

Yung, W.K., Albright, R.E., Olson, J., Fredericks, R., Fink, K., Prados, M.D., Brada, M., Spence, A., Hohl, R.J., Shapiro, W., Glantz, M., Greenberg, H., Selker, R.G., Vick, N.A., Rampling, R., Friedman, H., Phillips, P., Bruner, J., Yue, N., Osoba, D., Zaknoen, S., and Levin, V.A. (2000) A phase II study of temozolomide vs. procarbazine in patients with glioblastoma multiforme at first relapse. Br. J. Cancer 83,588 -593.[CrossRef][ISI][Medline]




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