|
|
|
|
|
|
||
|
|
||||
|
|
||||
|
||||
Medical Neuro-Oncology |
Department of Neurology (M.E., C.J.M.F.), and Department of Internal Medicine (F.J.F.J.), University Medical Center, Utrecht, The Netherlands
1 Address correspondence and reprint requests to Marijke Eurelings, Department of Neurology, University Medical Center, G03.228, P.O. Box 85500, 3508 GA Utrecht, The Netherlands.
Parathyroid carcinoma is an uncommon malignancy. Of the fewer than 400 cases reported, most have been cases of producing parathyroid carcinoma with accompanying hypercalcemia. Only 13 patients with nonproducing parathyroid carcinoma have been described. Nine of these 13 patients had metastatic disease. We report a patient with i.c. metastasis. Distal metastases of producing parathyroid carcinoma are treated surgically to prolong survival and prevent complications of hyperparathyroidism and hypercalcemia. One half of the patients with producing parathyroid carcinoma die within 5 years, mostly because of the complications of hypercalcemia. Nonproducing parathyroid carcinoma compares unfavorably with producing parathyroid carcinoma in terms of tumor progression and prognosis. Few data on choice of therapy in nonproducing parathyroid carcinoma are available. We treated our patient with a combination of radiotherapy and chemotherapy. Treatment was followed by an unexpectedly prolonged survival of 31 months after diagnosis of metastatic disease.
Aldinger, K.A., Hickey, R.C., Ibanez, M.L., and Samaan, N.A. (1982) Parathyroid carcinoma: A clinical study of seven cases of functioning and two cases of nonfunctioning parathyroid cancer. Cancer 49, 388-397.[CrossRef][ISI][Medline]
Armstrong, H.G. (1938) Primary carcinoma of the parathyroid with report of a case. Bull. Acad. M. Toronto 11, 105-110.
de Quervain, V.F. (1909) Parastruma maligna aberrata. Deut. Zschr. Chir. 100: 334-352.
Flye, M.W., and Brennan, M.F. (1981) Surgical resection of metastatic parathyroid carcinoma. Ann. Surg. 193: 425-435.[ISI][Medline]
Guy, C.C. (1929) Tumors of the parathyroid gland. Surg. Gynecol. Obstet. 48, 557-565.
Hainsworth, J.D., Johnson, D.H., and Greco, F.A. (1988) Poorly differentiated neuroendocrine carcinoma of unknown primary site: A newly recognized clinicopathologic entity. Ann. Intern. Med. 109, 364-371.[ISI][Medline]
Hall, E.M., and Chaffin, L. (1934) Malignant tumor of the parathyroid gland. West. J. Surg. 42, 578-586.
Koea, J.B., and Shaw, J.H. (1999) Parathyroid cancer: Biology and management. Surg. Oncol. 8, 155-165.[CrossRef][ISI][Medline]
Kytola, S., Farnebo, F., Obara, T., Isola, J., Grimelius, L., Farnebo, L.O., Sandelin, K., and Larsson, C. (2000) Patterns of chromosomal imbalances in parathyroid carcinomas. Am. J. Pathol. 157, 579-586.
McQuillain, A.S. (1938) Parathyroid tumor. Ann. Surg. 108, 464-468.[Medline]
Mendiola, R. (1942) Parathyroid carcinoma. Rev. Mex. Cir. 10, 387-394.
Merlano, M., Conte, P., Scarsi, P., Tatarek, R., Barbieri, A., Santelli, A., Scarpati, D., and De Angelis, P. (1985) Non-functioning parathyroid carcinoma: A case report. Tumori 71, 193-196.[ISI][Medline]
Moertel, C.G., Kvols, L.K., O'Connell, M.J., and Rubin, J. (1991) Treatment of neuroendocrine carcinomas with combined etoposide and cisplatin: Evidence of major therapeutic activity in the anaplastic variants of these neoplasms. Cancer 68, 227-232.[CrossRef][ISI][Medline]
Ordonez, N.G., Ibanez, M.L., Samaan, N.A., and Hickey, R.C. (1983) Immunoperoxidase study of uncommon parathyroid tumors: Report of two cases of nonfunctioning parathyroid carcinoma and one intrathyroid parathyroid tumor-producing amyloid. Am. J. Surg. Pathol. 7, 535-542.[ISI][Medline]
Pitale, S.U., Melian, E., Thomas, C., Moley, J.F., Origitano, T., and Sizemore, G.W. (1999) Brain metastases from medullary thyroid carcinoma in a patient with multiple endocrine neoplasia type 2A. Thyroid 9, 1123-1125.[ISI][Medline]
Posner, J.B. (1995) Intracranial metastases. In: Posner, J.B. (Ed.), Neurologic Complications of Cancer. Philadelphia: F.A. Davis. pp. 77-110.
Price, L.W., and Mowat, G.T. (1932) A case of rapidly-growing carcinoma in the neck, arising in a parathyroid rest. Br. J. Surg. 19, 645-650.
Roffo, A.H., and Landivar, Y.A.F. (1914) Case report. Prensa. Med. Argent. 2, 177-181.
Sato, M., Miyauchi, A., Namihira, H., Bhuiyan, M.M., Imachi, H., Murao, K., and Takahara, J. (2000) A newly recognized germline mutation of MEN1 gene identified in a patient with parathyroid adenoma and carcinoma. Endocrine 12, 223-226.[CrossRef][ISI][Medline]
Schantz, A., and Castleman, B. (1973) Parathyroid carcinoma: A study of 70 cases. Cancer 31, 600-605.[CrossRef][ISI][Medline]
Sieracki, J.C., and Horn, R.C., Jr. (1960) Nonfunctional carcinoma of the parathyroid gland. Cancer 13, 502-506.[CrossRef][ISI][Medline]
Toland, C.G. (1931) Tumors of the parathyroid gland. J. Am. Med. Assoc. 96, 741-744.
Tyler, D., III, Mandybur, G., Dhillon, G., and Fratkin, J. (2001) Intracranial metastatic parathyroid carcinoma: Case report. Neurosurgery 48, 937-940.[CrossRef][ISI][Medline]
Vetto, J.T., Brennan, M.F., Woodruf, J., and Burt, M. (1993) Parathyroid carcinoma: Diagnosis and clinical history. Surgery 114, 882-892.[ISI][Medline]
Wassif, W.S., Moniz, C.F., Friedman, E., Wong, S., Weber, G., Nordenskjold M., Peters, T.J., and Larsson, C. (1993) Familial isolated hyperparathyroidism: A distinct genetic entity with an increased risk of parathyroid cancer. J. Clin. Endocrinol. Metab. 77, 1485-1489.[Abstract]
Wynne, A.G., Van Heerden, J., Carney, J.A., and Fitzpatrick, L.A. (1992) Parathyroid carcinoma: Clinical and pathologic features in 43 patients. Medicine 71, 197-205.[Medline]
Yousem, D.M., Atlas, S.W., Grossman, R.I., Sergott, R.C., Savino, P.J., and Bosley, T.M. (1990) MR imaging of Tolosa-Hunt syndrome. AJR. Am. J. Roentgenol. 154, 167-170.
This article has been cited by other articles:
|
|
 |
|
  A. Artinyan, E. Guzman, E. Maghami, M. Al-Sayed, M. D'Apuzzo, L. Wagman, and J. Kim Metastatic Parathyroid Carcinoma to the Liver Treated With Radiofrequency Ablation and Transcatheter Arterial Embolization J. Clin. Oncol., August 20, 2008; 26(24): 4039 - 4041. [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Keane Bilateral Ocular Paralysis: Analysis of 31 Inpatients Arch Neurol, February 1, 2007; 64(2): 178 - 180. [Abstract] [Full Text] [PDF]
|
|
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|
