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Neuro Oncol 2000 2(3):190-191; DOI:10.1215/15228517-2-3-190
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Clinical Therapy Trails-Drug

Treatment of progressive metastatic glomus jugulare tumor (paraganglioma) with gemcitabine

J. Marc Pipas1 and Robert F. Krywicki

Dartmouth-Hitchcock Medical Center/Norris Cotton Cancer Center, Lebanon, NH 03756 (J.M.P.); and Phoebe Putney Memorial Hospital/Phoebe Cancer Center, Albany, GA 31701 (R.F.K.)

1 Address correspondence and reprint requests to Marc Pipas, Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756.

Abstract

Paragangliomas are rare tumors of the paraganglia composed of specialized neural crest cells arising in association with sympathetic ganglia. Here we report a case of progressive, metastatic paraganglioma (glomus jugulare tumor) responsive to single agent gemcitabine. In addition, a brief review of chemotherapy for paraganglioma follows the case presentation.

References

Cairnduff, F., and Smith, I.E. (1986) Carboplatin chemotherapy for malignant paraganglioma. Lancet 2, 982. (letter)

Gabriel, E.M., Sampson, J.H., Dodd, L.G., and Turner, D.A. (1995) Glomus jugulare tumor metastatic to the sacrum after high-dose radiation therapy: Case report. Neurosurgery, 37,1001 -1005.[Medline]

Massey, V., and Wallner, K. (1992) Treatment of metastatic chemodectoma. Cancer 69,790 -792.[Medline]

Mertens, W.C., Grignon, D.J., and Romano, W. (1993) Malignant paraganglioma with skeletal metastases and spinal cord compression: Response and palliation with chemotherapy. Clin. Oncol. 5,126 -128.[CrossRef]

Patel, S.R., Winchester, DJ., and Benjamin, R.S. (1995) A fifteen year experience with chemotherapy of patients with paraganglioma. Cancer 76,1476 -1480.[CrossRef][Web of Science][Medline]

Zak, F.G., and Lawson, W. (1982) The Paraganglionic Chemoreceptor System: Physiology, Pathology, and Clinical Medicine. New York: Springer-Verlag.


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