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Clinical Therapy Trials—Quality of Life |
The University of Texas, M.D. Anderson Cancer Center, Houston, TX 77030 (A.E.D., B.D.M., J.M.S., J.L.A., D.R.C.); and The University of Texas-Houston, Medical School, Houston, TX 77030 (J.M.S.)
2 Address correspondence and reprint requests to Bartlett D. Moore, III, Ph.D., Division of Pediatrics, Box 87, U.T. M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030.
Abstract
Neurofibromatosis type 1 is a common autosomal dominant genetic disorder associated with numerous physical anomalies and an increased incidence of neuropsychological impairment. Tumors of the CNS occur in approximately 15% of children with neurofibromatosis, presenting additional risk for cognitive impairment. This study examines the impact of an additional diagnosis of brain tumor on the cognitive profile of children with neurofibromatosis. A comprehensive battery of neuropsychological tests was administered to 149 children with neurofibromatosis. Thirty-six of these children had a codiagnosis of brain tumor. A subset of 36 children with neurofibromatosis alone was matched with the group of children diagnosed with neurofibromatosis and brain tumor. Although mean scores of the neurofibromatosis plus brain tumor group were, in general, lower than those of the neurofibromatosis alone group, these differences were not statistically significant. Children in the neurofibromatosis plus brain tumor group who received cranial irradiation (n = 9) demonstrated weaker academic abilities than did children with brain tumor who had not received that treatment. These results suggest that neurofibromatosis is associated with impairments in cognitive functioning, but the severity of the problems is not significantly exacerbated by the codiagnosis of a brain tumor unless treatment includes cranial irradiation.
References
Beery, K., and Butenika, N. (1967) Developmental Test of Visual-Motor Integration. Chicago, Ill.: Follett Education Co.
Brookshire, B., Copeland, D.R., Moore, B.D., and Ater, J.L. (1990) Pretreatment neuropsychological status and associated factors in children with primary brain tumors. Neurosurgery 27,887 -891.[CrossRef][Web of Science][Medline]
Buschke, H., and Fuld, P.A. (1974) Evaluating storage, retention, and retrieval in disordered memory and learning. Neurology 24,1019 -1025.
Cohen, B.H., Kaplan, A.M., and Packer, R.J. (1990–91) Management of intracranial neoplasms in children with neurofibromatosis type 1 and 2. Pediatr. Neurosurg. 16,66 -72.[Web of Science][Medline]
Cohen, M.E., Duffner, P.K., Kuhn, J.P., and Seidel, F.G. (1986) Neuroimaging in neurofibromatosis. Ann. Neurol. 20,444 .
Copeland, D.R., and Moore, B.D. (1992) Neuropsychological outcome among children treated at M.D. Anderson Cancer Center. Can. Bull. 44,509 -517.
Copeland, D.R., Fletcher, J.M., Pfefferbaum-Levine, B., Jaffe, N.,
Ried, H., and Maor, M. (1985) Neuropsychological sequelae of
childhood cancer in long-term survivors. Pediatrics
75,745
-753.
Copeland, D.R., Dowell, R.E., Jr., Fletcher, J.M., Bordeaux, J.D.,
Sullivan, M.P., Jaffe, N., Frankel, L.S., Ried, H.L., and Cangir, A.
(1988) Neuropsychological effects of childhood cancer treatment.
J. Child. Neurol. 3,53
-62.
Crossen, J.R., Garwood, D., Glatstein, E., and Neuwelt, E.A. (1994) Neurobehavioral sequelae of cranial irradiation in adults: A review of radiation-induced encephalopathy. J. Clin. Oncol. 12,627 -642.[Abstract]
Denckla, M.B., and Rudel, R. (1974) Rapid "automatized" naming of pictured objects, colors, letters, and numbers by normal children. Cortex 10,186 -202.[Medline]
Denckla, M.B., Hofman, K., Mazzocco, M.M., Melhem, E., Reiss, A.L., Bryan, R.N., Harris, E.L., Lee, J., Cox, C.S., and Schuerholz, L.J. (1996) Relationship between T2-weighted hyperintensities (unidentified bright objects) and lower IQs in children with neurofibromatosis-1. Am. J. Med. Genet. 67, 98-102.[CrossRef][Web of Science][Medline]
Duffner, P.K., Cohen, M.E., Seidel, F.G., and Shucard, D.W.
(1989) The significance of MRI abnormalities in children with
neurofibromatosis. Neurology
39,373
-378.
Eldridge, R., Denckla, M.B., Bien, E., Myers, S., Kaiser-Kupfer,
M.I., Pikus, A., Schlesinger, S.L., Parry, D.M., Dambrosia, J.M., Zasloff,
M.A., Mulvihill, J.J. (1989) Neurofibromatosis type 1
(Recklinghausen's disease): Neurologic and cognitive assessment with sibling
controls. Am. J. Dis. Child.
143,833
-837.
Eliason, M.J. (1986) Neurofibromatosis: Implications for learning and behavior. J. Dev. Behav. Pediatr. 7, 175-179.[Web of Science][Medline]
Ferner, R.E., Chaudhuri, R., Bingham, J., Cos, T., and Hughes,
R.A.C. (1993) MRI in neurofibromatosis 1: The nature and
evolution of increased intensity T2 weighted lesions and their relationship to
intellectual impairment. J. Neurol. Neurosurg.
Psychiatry 56,492
-495.
Fletcher, J.M. (1985) Memory for verbal and nonverbal stimuli in learning disabled subgroups: Analysis by selective reminding. J. Exp. Child Psychol. 40,244 -259.[CrossRef][Web of Science][Medline]
Fletcher, J.M., and Copeland, D.R. (1988) Neurobehavioral effects of central nervous system prophylactic treatment of cancer in children. J. Clin. Exp. Neuropsychol. 10,495 -537.[Web of Science][Medline]
Gaddes, W.H., and Crockett, D.J. (1975) The Spreen-Benton aphasia tests: Normative data as a measure of normal language development. Brain Lang. 2, 257-280.[CrossRef][Web of Science][Medline]
Hofman, K.J., Harris, E.L., Bryan, R.N., and Denckla, M.B. (1994) Neurofibromatosis type 1: The cognitive phenotype. J. Pediatr. 124,S1 -S8.[CrossRef][Web of Science][Medline]
Hollingshead, A.B. (1975) Four Factor Index of Social Status. New Haven, Conn.: Yale University.
Jastak, S.R., and Wilkinson, G.S. (1984) WRAT-R: Wide Range Achievement Test-Revised Administration Manual. Wilmington, Del.: Jastak Associates, Inc.
Joy, P., Roberts, C., North, K., and de Silva, M. (1995) Neuropsychological function and MRI abnormalities in neurofibromatosis type I. Dev. Med. Child Neurol. 37,906 -914.[Web of Science][Medline]
Legius, E., Descheemaeker, M.J., Spaepen, A., Casaer, P., and Fryns, J.P. (1994) Neurofibromatosis type 1 in childhood: A study of the neuropsychological profile in 45 children. Genet. Counseling 5,51 -60.
Leiner, H.C., Leiner, A.L., and Dow, R.S. (1991) The human cerebro-cerebellar system: Its computing, cognitive, and language skills. Behav. Brain Res. 44,113 -128.[Web of Science][Medline]
Lindgren, S.D., and Benton, A.L. (1980) Developmental
patterns of visuospatial judgment. J. Pediatr.
Psychol. 5,217
-225.
Listernick, R., Charrow, J., Greenwald, M.J., and Easterly, N.B. (1989) Optic gliomas in children with neurofibromatosis type 1. J. Pediatr. 114,788 -792.[CrossRef][Medline]
Listernick, R., Charrow, J., and Greenwald, M. (1992) Emergence of optic pathway gliomas in children with neurofibromatosis type 1 after normal neuroimaging results. J. Pediatr. 121,584 -587.[CrossRef][Web of Science][Medline]
Listernick, R., Charrow, J., Greenwald, M., and Mets, M. (1994) Natural history of optic pathway tumors in children with neurofibromatosis type 1: A longitudinal study. J. Pediatr. 125,63 -66.[CrossRef][Web of Science][Medline]
Mazzocco, M.M., Turner, J.E., Denckla, M.B., Hofman, K.J., Scanlon, D.C., and Vellutino, F.R. (1997) Language and reading deficits associated with neurofibromatosis type 1: Evidence for a not-so-nonverbal learning disability. Dev. Neuropsychol. 11,504 -522.
McCarthy, D. (1972) McCarthy Scales of Children's Abilities. New York, N.Y.: The Psychological Corporation.
Moore, B.D., III, Ater, J.L., Needle, M.N., Slopis, J., and
Copeland, D.R. (1994) Neuropsychological profile of children with
neurofibromatosis, brain tumor, or both. J. Child
Neurol. 9,368
-377.
Moore, B.D., Slopis, J.M., Schomer, D., Jackson, E.F., and Levy,
B.M. (1996) Neuropsychological significance of areas of high
signal intensity on brain MRIs of children with neurofibromatosis.
Neurology 46,1660
-1668.
Mulvihill, J.J., Parry, D.M., Sherman, J.L., Pikus, A., Kaiser-Kupfer, M.I., and Eldridge, R. (1990) NIH conference. Neurofibromatosis 1 (Recklinghausen disease) and neurofibromatosis 2 (bilateral acoustic neurofibromatosis): An update. Ann. Internal Med. 113,39 -52.
NIH (National Institutes of Health) (1988)
Neurofibromatosis conference statement. National Institutes of Health
consensus Development Conference. Arch. Neurol.
45,575
-578.
North, K., Joy, P., Yuille, D., Cocks, N., Mobbs, E., Hutchins, P.,
McHugh, K., and de Silva, M. (1994) Specific learning disability
in children with neurofibromatosis type 1: Significance of MRI abnormalities.
Neurology 44,878
-883.
North, K.N., Riccardi, V., Samango-Sprouse, C., Ferner, R., Moore,
B., Legius, E., Ratner, N., and Denckla, M.B. (1997) Cognitive
function and academic performance in neurofibromatosis 1: Consensus statement
from the NF1 Cognitive Disorders Task Force. Neurology
48,1121
-1127.
Packer, R.J., Meadows, A.T., Rorke, L.B., Goldwein, J.L., and D'Angio, G. (1987) Long-term sequelae of cancer treatment on the central nervous system in childhood. Med. Pediatr. Oncol. 15,241 -253.[Web of Science][Medline]
Reitan, R. (1969) Manual for Administration of Neuropsychological Test Batteries on Adults and Children. Bloomington, Ind.: Indiana University Press.
Riccardi, V.M. (1981) Von Recklinghausen neurofibromatosis. N. Engl. J. Med. 305,1617 -1627.[Web of Science][Medline]
Riccardi, V.M. (1982) The multiple forms of
neurofibromatosis. Pediatr. Rev.
3, 293-298.
Ris, M.D., and Noll, R.B. (1994) Long-term neurobehavioral outcome in pediatric brain-tumor patients: Review and methodological critique. J. Clin. Exp. Neuropsychol. 16, 21-42.[Web of Science][Medline]
Roos, K.L., and Dunn, D.W. (1992) Neurofibromatoses. CA Cancer J. Clin. 42,241 -254.[Web of Science][Medline]
Rosner, J., and Simon, D.P. (1971) The Auditory Analysis Test: An initial report. J. Learn. Dis. 7, 40-47.
Satz, P., and Fletcher, J.M. (1982) The Florida Kindergarten Screening Battery. Odessa, Fla.: Psychological Assessment Resources, Inc.
Stine, S.B., and Adams, W.V. (1989) Learning problems in neurofibromatosis patients. Clin. Orthop. 245, 43-48.
Thorndike, R.L., Hagen, E.P., and Sattler, J.M. (1986)Stanford-Binet Intelligence Scale: Guide for Administering and Scoring the Fourth Edition. Fourth edition . Chicago: The Riverside Publishing Company.
Varnhagen, C.K., Lewin, S., Das, J.P., Bowen, P., Ma, K., and Klimek, M. (1988) Neurofibromatosis and psychological processes. J. Dev. Behav. Pediatr. 9, 257-265.[Web of Science][Medline]
Wadsby, M., Lindehammar, H., and Eeg-Olofsson, O. (1989) Neurofibromatosis in childhood: Neuropsychological aspects. Neurofibromatosis 2, 251-260.[Medline]
Wechsler, D. (1974) WISC-R, Manual for the Wechsler Intelligence Scale for Children-Revised. New York, N.Y.: The Psychological Corporation.
Wechsler, D. (1991) Wechsler Intelligence Scale for Children. Third edition. New York, N.Y.: Harcourt, Brace, Jovancovich, Inc.,
Woodcock, R.W., Johnson, M.B., and Mather, N. (1989) Woodcock Johnson Psycho-Educational Battery-Revised. Allen, Texas: DLM Teaching Resources.
Wright, T.L., and Bresnan, M.J. (1976)
Radiation-induced cerebrovascular disease in children.
Neurology 26,540
-543.
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