Home Duke University Press
 QUICK SEARCH:   [advanced]


     
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents


Neuro Oncol 1999 1(4):275-281; DOI:10.1215/15228517-1-4-275
This Article
Right arrow Abstract Freely available
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by De Winter, A. E.
Right arrow Articles by Copeland, D. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Duke University Press

Clinical Therapy Trials—Quality of Life

Brain tumors in children with neurofibromatosis: Additional neuropsychological morbidity?

Anne E. De Winter, Bartlett D. Moore, III2, John M. Slopis, Joann L. Ater and Donna R. Copeland

The University of Texas, M.D. Anderson Cancer Center, Houston, TX 77030 (A.E.D., B.D.M., J.M.S., J.L.A., D.R.C.); and The University of Texas-Houston, Medical School, Houston, TX 77030 (J.M.S.)

2 Address correspondence and reprint requests to Bartlett D. Moore, III, Ph.D., Division of Pediatrics, Box 87, U.T. M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030.

Abstract

Neurofibromatosis type 1 is a common autosomal dominant genetic disorder associated with numerous physical anomalies and an increased incidence of neuropsychological impairment. Tumors of the CNS occur in approximately 15% of children with neurofibromatosis, presenting additional risk for cognitive impairment. This study examines the impact of an additional diagnosis of brain tumor on the cognitive profile of children with neurofibromatosis. A comprehensive battery of neuropsychological tests was administered to 149 children with neurofibromatosis. Thirty-six of these children had a codiagnosis of brain tumor. A subset of 36 children with neurofibromatosis alone was matched with the group of children diagnosed with neurofibromatosis and brain tumor. Although mean scores of the neurofibromatosis plus brain tumor group were, in general, lower than those of the neurofibromatosis alone group, these differences were not statistically significant. Children in the neurofibromatosis plus brain tumor group who received cranial irradiation (n = 9) demonstrated weaker academic abilities than did children with brain tumor who had not received that treatment. These results suggest that neurofibromatosis is associated with impairments in cognitive functioning, but the severity of the problems is not significantly exacerbated by the codiagnosis of a brain tumor unless treatment includes cranial irradiation.

References

Beery, K., and Butenika, N. (1967) Developmental Test of Visual-Motor Integration. Chicago, Ill.: Follett Education Co.

Brookshire, B., Copeland, D.R., Moore, B.D., and Ater, J.L. (1990) Pretreatment neuropsychological status and associated factors in children with primary brain tumors. Neurosurgery 27,887 -891.[CrossRef][ISI][Medline]

Buschke, H., and Fuld, P.A. (1974) Evaluating storage, retention, and retrieval in disordered memory and learning. Neurology 24,1019 -1025.

Cohen, B.H., Kaplan, A.M., and Packer, R.J. (1990–91) Management of intracranial neoplasms in children with neurofibromatosis type 1 and 2. Pediatr. Neurosurg. 16,66 -72.[ISI][Medline]

Cohen, M.E., Duffner, P.K., Kuhn, J.P., and Seidel, F.G. (1986) Neuroimaging in neurofibromatosis. Ann. Neurol. 20,444 .

Copeland, D.R., and Moore, B.D. (1992) Neuropsychological outcome among children treated at M.D. Anderson Cancer Center. Can. Bull. 44,509 -517.

Copeland, D.R., Fletcher, J.M., Pfefferbaum-Levine, B., Jaffe, N., Ried, H., and Maor, M. (1985) Neuropsychological sequelae of childhood cancer in long-term survivors. Pediatrics 75,745 -753.[Abstract/Free Full Text]

Copeland, D.R., Dowell, R.E., Jr., Fletcher, J.M., Bordeaux, J.D., Sullivan, M.P., Jaffe, N., Frankel, L.S., Ried, H.L., and Cangir, A. (1988) Neuropsychological effects of childhood cancer treatment. J. Child. Neurol. 3,53 -62.[Abstract/Free Full Text]

Crossen, J.R., Garwood, D., Glatstein, E., and Neuwelt, E.A. (1994) Neurobehavioral sequelae of cranial irradiation in adults: A review of radiation-induced encephalopathy. J. Clin. Oncol. 12,627 -642.[Abstract]

Denckla, M.B., and Rudel, R. (1974) Rapid "automatized" naming of pictured objects, colors, letters, and numbers by normal children. Cortex 10,186 -202.[Medline]

Denckla, M.B., Hofman, K., Mazzocco, M.M., Melhem, E., Reiss, A.L., Bryan, R.N., Harris, E.L., Lee, J., Cox, C.S., and Schuerholz, L.J. (1996) Relationship between T2-weighted hyperintensities (unidentified bright objects) and lower IQs in children with neurofibromatosis-1. Am. J. Med. Genet. 67, 98-102.[CrossRef][ISI][Medline]

Duffner, P.K., Cohen, M.E., Seidel, F.G., and Shucard, D.W. (1989) The significance of MRI abnormalities in children with neurofibromatosis. Neurology 39,373 -378.[Abstract/Free Full Text]

Eldridge, R., Denckla, M.B., Bien, E., Myers, S., Kaiser-Kupfer, M.I., Pikus, A., Schlesinger, S.L., Parry, D.M., Dambrosia, J.M., Zasloff, M.A., Mulvihill, J.J. (1989) Neurofibromatosis type 1 (Recklinghausen's disease): Neurologic and cognitive assessment with sibling controls. Am. J. Dis. Child. 143,833 -837.[Abstract]

Eliason, M.J. (1986) Neurofibromatosis: Implications for learning and behavior. J. Dev. Behav. Pediatr. 7, 175-179.[ISI][Medline]

Ferner, R.E., Chaudhuri, R., Bingham, J., Cos, T., and Hughes, R.A.C. (1993) MRI in neurofibromatosis 1: The nature and evolution of increased intensity T2 weighted lesions and their relationship to intellectual impairment. J. Neurol. Neurosurg. Psychiatry 56,492 -495.[Abstract]

Fletcher, J.M. (1985) Memory for verbal and nonverbal stimuli in learning disabled subgroups: Analysis by selective reminding. J. Exp. Child Psychol. 40,244 -259.[CrossRef][ISI][Medline]

Fletcher, J.M., and Copeland, D.R. (1988) Neurobehavioral effects of central nervous system prophylactic treatment of cancer in children. J. Clin. Exp. Neuropsychol. 10,495 -537.[ISI][Medline]

Gaddes, W.H., and Crockett, D.J. (1975) The Spreen-Benton aphasia tests: Normative data as a measure of normal language development. Brain Lang. 2, 257-280.[CrossRef][ISI][Medline]

Hofman, K.J., Harris, E.L., Bryan, R.N., and Denckla, M.B. (1994) Neurofibromatosis type 1: The cognitive phenotype. J. Pediatr. 124,S1 -S8.[CrossRef][ISI][Medline]

Hollingshead, A.B. (1975) Four Factor Index of Social Status. New Haven, Conn.: Yale University.

Jastak, S.R., and Wilkinson, G.S. (1984) WRAT-R: Wide Range Achievement Test-Revised Administration Manual. Wilmington, Del.: Jastak Associates, Inc.

Joy, P., Roberts, C., North, K., and de Silva, M. (1995) Neuropsychological function and MRI abnormalities in neurofibromatosis type I. Dev. Med. Child Neurol. 37,906 -914.[ISI][Medline]

Legius, E., Descheemaeker, M.J., Spaepen, A., Casaer, P., and Fryns, J.P. (1994) Neurofibromatosis type 1 in childhood: A study of the neuropsychological profile in 45 children. Genet. Counseling 5,51 -60.

Leiner, H.C., Leiner, A.L., and Dow, R.S. (1991) The human cerebro-cerebellar system: Its computing, cognitive, and language skills. Behav. Brain Res. 44,113 -128.[ISI][Medline]

Lindgren, S.D., and Benton, A.L. (1980) Developmental patterns of visuospatial judgment. J. Pediatr. Psychol. 5,217 -225.[Abstract/Free Full Text]

Listernick, R., Charrow, J., Greenwald, M.J., and Easterly, N.B. (1989) Optic gliomas in children with neurofibromatosis type 1. J. Pediatr. 114,788 -792.[CrossRef][Medline]

Listernick, R., Charrow, J., and Greenwald, M. (1992) Emergence of optic pathway gliomas in children with neurofibromatosis type 1 after normal neuroimaging results. J. Pediatr. 121,584 -587.[CrossRef][ISI][Medline]

Listernick, R., Charrow, J., Greenwald, M., and Mets, M. (1994) Natural history of optic pathway tumors in children with neurofibromatosis type 1: A longitudinal study. J. Pediatr. 125,63 -66.[CrossRef][ISI][Medline]

Mazzocco, M.M., Turner, J.E., Denckla, M.B., Hofman, K.J., Scanlon, D.C., and Vellutino, F.R. (1997) Language and reading deficits associated with neurofibromatosis type 1: Evidence for a not-so-nonverbal learning disability. Dev. Neuropsychol. 11,504 -522.

McCarthy, D. (1972) McCarthy Scales of Children's Abilities. New York, N.Y.: The Psychological Corporation.

Moore, B.D., III, Ater, J.L., Needle, M.N., Slopis, J., and Copeland, D.R. (1994) Neuropsychological profile of children with neurofibromatosis, brain tumor, or both. J. Child Neurol. 9,368 -377.[Abstract/Free Full Text]

Moore, B.D., Slopis, J.M., Schomer, D., Jackson, E.F., and Levy, B.M. (1996) Neuropsychological significance of areas of high signal intensity on brain MRIs of children with neurofibromatosis. Neurology 46,1660 -1668.[Abstract/Free Full Text]

Mulvihill, J.J., Parry, D.M., Sherman, J.L., Pikus, A., Kaiser-Kupfer, M.I., and Eldridge, R. (1990) NIH conference. Neurofibromatosis 1 (Recklinghausen disease) and neurofibromatosis 2 (bilateral acoustic neurofibromatosis): An update. Ann. Internal Med. 113,39 -52.

NIH (National Institutes of Health) (1988) Neurofibromatosis conference statement. National Institutes of Health consensus Development Conference. Arch. Neurol. 45,575 -578.[ISI][Medline]

North, K., Joy, P., Yuille, D., Cocks, N., Mobbs, E., Hutchins, P., McHugh, K., and de Silva, M. (1994) Specific learning disability in children with neurofibromatosis type 1: Significance of MRI abnormalities. Neurology 44,878 -883.[Abstract/Free Full Text]

North, K.N., Riccardi, V., Samango-Sprouse, C., Ferner, R., Moore, B., Legius, E., Ratner, N., and Denckla, M.B. (1997) Cognitive function and academic performance in neurofibromatosis 1: Consensus statement from the NF1 Cognitive Disorders Task Force. Neurology 48,1121 -1127.[ISI][Medline]

Packer, R.J., Meadows, A.T., Rorke, L.B., Goldwein, J.L., and D'Angio, G. (1987) Long-term sequelae of cancer treatment on the central nervous system in childhood. Med. Pediatr. Oncol. 15,241 -253.[ISI][Medline]

Reitan, R. (1969) Manual for Administration of Neuropsychological Test Batteries on Adults and Children. Bloomington, Ind.: Indiana University Press.

Riccardi, V.M. (1981) Von Recklinghausen neurofibromatosis. N. Engl. J. Med. 305,1617 -1627.[ISI][Medline]

Riccardi, V.M. (1982) The multiple forms of neurofibromatosis. Pediatr. Rev. 3, 293-298.[Abstract/Free Full Text]

Ris, M.D., and Noll, R.B. (1994) Long-term neurobehavioral outcome in pediatric brain-tumor patients: Review and methodological critique. J. Clin. Exp. Neuropsychol. 16, 21-42.[ISI][Medline]

Roos, K.L., and Dunn, D.W. (1992) Neurofibromatoses. CA Cancer J. Clin. 42,241 -254.[ISI][Medline]

Rosner, J., and Simon, D.P. (1971) The Auditory Analysis Test: An initial report. J. Learn. Dis. 7, 40-47.

Satz, P., and Fletcher, J.M. (1982) The Florida Kindergarten Screening Battery. Odessa, Fla.: Psychological Assessment Resources, Inc.

Stine, S.B., and Adams, W.V. (1989) Learning problems in neurofibromatosis patients. Clin. Orthop. 245, 43-48.

Thorndike, R.L., Hagen, E.P., and Sattler, J.M. (1986)Stanford-Binet Intelligence Scale: Guide for Administering and Scoring the Fourth Edition. Fourth edition . Chicago: The Riverside Publishing Company.

Varnhagen, C.K., Lewin, S., Das, J.P., Bowen, P., Ma, K., and Klimek, M. (1988) Neurofibromatosis and psychological processes. J. Dev. Behav. Pediatr. 9, 257-265.[ISI][Medline]

Wadsby, M., Lindehammar, H., and Eeg-Olofsson, O. (1989) Neurofibromatosis in childhood: Neuropsychological aspects. Neurofibromatosis 2, 251-260.[Medline]

Wechsler, D. (1974) WISC-R, Manual for the Wechsler Intelligence Scale for Children-Revised. New York, N.Y.: The Psychological Corporation.

Wechsler, D. (1991) Wechsler Intelligence Scale for Children. Third edition. New York, N.Y.: Harcourt, Brace, Jovancovich, Inc.,

Woodcock, R.W., Johnson, M.B., and Mather, N. (1989) Woodcock Johnson Psycho-Educational Battery-Revised. Allen, Texas: DLM Teaching Resources.

Wright, T.L., and Bresnan, M.J. (1976) Radiation-induced cerebrovascular disease in children. Neurology 26,540 -543.[Abstract/Free Full Text]




This article has been cited by other articles:


Home page
Arch NeurolHome page
R. L. Billingsley, G. W. Schrimsher, E. F. Jackson, J. M. Slopis, and B. D. Moore III
Significance of Planum Temporale and Planum Parietale Morphologic Features in Neurofibromatosis Type 1
Arch Neurol, April 1, 2002; 59(4): 616 - 622.
[Abstract] [Full Text] [PDF]


This Article
Right arrow Abstract Freely available
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by De Winter, A. E.
Right arrow Articles by Copeland, D. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation


  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents


Copyright 1999 by Society for Neuro-Oncology