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Neuro Oncol 1999 1(2):152-161; DOI:10.1215/15228517-1-2-152
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Duke University Press

Symposium Childhood Brian Tumors

The treatment of malignant brain tumors in infants and very young children: An update of the Pediatric Oncology Group experience

Patricia K. Duffner, Marc E. Horowitz, Jeffrey P. Krischer, Peter C. Burger, Michael E. Cohen, Robert A. Sanford, Henry S. Friedman, Larry E. Kun the Pediatric Oncology Group (POG)1

The State University of New York at Buffalo School of Medicine and Biomedical Sciences, Buffalo, NY 14222, and the Roswell Park Cancer Institute, Buffalo, NY 14263 [P.K.D., M.E.C.]; Baylor College of Medicine, Houston, TX 77030 [M.E.H.]; H. Lee Moffitt Cancer Center, Tampa, FL 33612 [J.P.K.]; The Johns Hopkins Hospital, Baltimore, MD 21287 [P.C.B.]; St. Jude Children's Research Hospital, Memphis, TN 38101 [R.A.S., L.E.K.]; Duke University Medical Center, Durham, NC 27710 [H.S.F.]; and the Pediatric Oncology Group, Chicago, IL 60611

1 Address correspondence and reprints requests to Patricia K. Duffner, M.D., Children's Hospital of Buffalo, Department of Neurology, 219 Bryant Street, Buffalo, NY 14222.

References

Albright, A.L. (1985) Brain tumors in neonates, infants, and toddlers. Contemp. Neurosurg. 7, 1-6.

Asai, A., Hoffman, H.J., Hendrick, E.B., Humphreys, R.P., and Becker, L.E. (1989) Primary intracranial neoplasms in the first year of life. Childs Nerv. Syst. 5, 230-233.[CrossRef][ISI][Medline]

Ater, J.L., van Eys, J., Woo, S.Y., Moore, B., III, Copeland, D.R., and Bruner, J. (1997) MOPP chemotherapy without irradiation as primary postsurgical therapy for brain tumors in infants and young children. J. Neurooncol. 32,243 -252.[CrossRef][Medline]

Bloom, H.J.G., Glees, J., Bell, J., Ashley, S.E., and Gorman, C. (1990) The treatment and long-term prognosis of children with intracranial tumors: A study of 610 cases, 1950-1981. Int. J. Rad. Oncol. Biol. Phys. 18,723 -745.[ISI][Medline]

Cohen, B.H., Packer, R.J., Siegel, K.R., Rorke, L.B., D'Angio, G., Sutton, L.N., Bruce, D.A., and Schut, L. (1993) Brain tumors in children under 2 years: Treatment, survival and long-term prognosis. Pediatr. Neurosurg. 19,171 -179.[ISI][Medline]

Cohen, B.H., Zeltzer, P.M., Boyett, J.M., Geyer, J.R., Allen, J.C., Finlay, J.L., McGuire-Cullen, P., Milstein, J.M. Rorke, L.B., Stanley, P., Stehbens, J.A., Shurin, S.B., Wisoff, J., Stevens, K., and Albright, A.C. (1995) Prognostic factors and treatment results for supratentorial primitive neuroectodermal tumors in children using radiation and chemotherapy: A Childrens Cancer Group randomized trial. J. Clin. Oncol. 13,1687 -1696.[Medline]

Cohen, M.E., and Duffner, P.K. (1994) Brain Tumors in Children: Principles of Diagnosis and Treatment. Second edition. New York: Raven Press, Ltd.

Duffner, P.K., and Cohen, M.E. (1991) Long-term consequences of CNS treatment of childhood cancer. Part II: Clinical consequences. Pediatr. Neurol. 7, 237-242.[Medline]

Duffner, P.K., and Cohen, M.E. (1997) Primitive neuroectodermal tumors. In: Vinken, P.J., and Bruyn, G.W. (Eds.), Handbook of Clinical Neurology, Vol.68 . Neuro-Oncology, Part II, Vecht, C.J. (Ed.). pp.211 -227.

Duffner, P.K., Cohen, M.E., Myers, M.M., and Heise, H.W. (1986) Survival of children with brain tumors: SEER Program 1973-1980. Neurology 36,597 -601.[Abstract/Free Full Text]

Duffner, P.K., Cohen, M.E., Sanford, R.A., Horowitz, M.E., Krischer, J.P., Burger, P.C., Friedman, H.S., and Kun, L.E. (1995) Lack of efficacy of postoperative chemotherapy and delayed radiation in very young children with pineoblastoma. Med. Pediatr. Oncol. 25,38 -44.[Medline]

Duffner, P.K., Horowitz, M.E., Krischer, J.P., Friedman, H.S., Burger, P.C., Cohen, M.E., Sanford, R.A., Mulher, R.K., James, H.E., Freeman, C.R., Seidel, F.E., and Kun, L.E. (1993) Postoperative chemotherapy and delayed radiation in children less than 3 years of age with malignant brain tumors. N. Engl. J. Med. 328,1725 -1731.[Abstract/Free Full Text]

Duffner, P.K., Krischer, J.P., Burger, P.C., Cohen, M.E., Backstrom, J.W., Horowitz, M.E., Sanford, R.A., Friedman, H.S., and Kun, L.E. (1996) Treatment of infants with malignant gliomas: The Pediatric Oncology Group Experience. J. Neurooncol. 28,245 -256.[Medline]

Duffner, P.K., Krischer, J.P., Sanford, R.A., Horowitz, M.E., Burger, P.C., Cohen, M.E., Friedman, H.S., and Kun, L.E. (1998a) Prognostic factors in infants and very young children with intracranial ependymomas. Pediatr. Neurosurg. 28,215 -222.[CrossRef][Medline]

Duffner, P.K., Krischer, J.P., Horowitz, M.G., Cohen, M.E., Burger, P.C., Friedman, H.S., and Kun, L.E. (1998b) Second malignancies in young children with primary brain tumors following treatment with prolonged postoperative chemotherapy and delayed irradiation: A Pediatric Oncology Group study. Ann. Neurol. 44,313 -316.[CrossRef][ISI][Medline]

Dupuis-Girod, S., Hartmann, O., Benhamou, E., Doz, F., Mechinaud, F., Bouffet, E., Coze, C., and Kalifa, C. (1996) Will high dose chemotherapy followed by autologous bone marrow transplantation supplant cranio-spinal irradiation in young children treated for medulloblastoma? J. Neurooncol. 27,87 -98.[CrossRef][Medline]

Farwell, J.R., Dohrmann, G.J., and Flannery, J.T. (1978) Intracranial neoplasms in infants. Arch. Neurol. 35,533 -537.[Abstract]

Fisher, P.G., Needle, M.N., Cnaan, A., Zhao, H., Geyer, J.R., Molloy, P.T., Goldwein, J.W., Herman-Liu, A.B., and Phillips, P.C. (1998) Salvage therapy after postoperative chemotherapy for primary brain tumors in infants and very young children. Cancer 83,566 -574.[CrossRef][Medline]

Gajjar, A., Mulhern, R.K., Heideman, R.L., Sanford, R.A., Douglass, E.C., Kovnar, E.H., Langston, J.A., Jenkins, J.J., and Kun, L.E. (1994) Medulloblastoma in very young children: Outcome of definitive craniospinal irradiation following incomplete response to chemotherapy. J. Clin. Oncol. 12,1212 -1216.[Abstract/Free Full Text]

Geyer, J.R., Finlay, J.L., Boyett, J.M., Wisoff, J., Yates, A., Mao, L., and Packer, R.J. (1995) Survival of infants with malignant astrocytomas. A report of the Children's Cancer Group. Cancer 75,1045 -1050.[CrossRef][ISI][Medline]

Geyer, J.R., Zeltzer, P.M., Boyett, JM., Rorke, L.B., Stanley, P., Albright, A.L., Wisoff, J.H., Milstein, J.M., Allen, J.C., Finlay, J.L., Ayers, G.D., Shurin, S.B., Stevens, K., and Bleyer, W.A. (1994) Survival of infants with primitive neuroectodermal tumors or malignant ependymomas of the CNS treated with eight drugs in 1 day: A report from the Children's Cancer Group. J. Clin. Oncol. 12,1607 -1615.[Abstract/Free Full Text]

Goldwein, J., Radcliffe, J., Packer, R.J., Sutton, L.N., Lange, B., Rorke, L.B., and D'Angio, G.J. (1993) Results of a pilot study of low-dose craniospinal radiation therapy plus chemotherapy for children younger than 5 years with primitive neuroectodermal tumors. Cancer 71,2647 -2652.[CrossRef][Medline]

Grill, J., Kalifa, C., Doz, F., Schoepfer, C., Sainte-Ross, C., Couanet, D., Terrier-Lacombe, M.J., Valteau-Couanet, D., and Hartmann, O. (1996) A high-dose busulfan-thiotepa combination followed by autologous bone marrow transplantation in childhood recurrent ependymoma. A phase II study. Pediatr. Neurosurg. 25, 7-12.[Medline]

Guruangan, S., Dunkel, I.J., Goldman, S., Garvin, J.H., Rosenblum, M., Boyett, J.M., Gardner, S., Merchant, T.E., Gollamudi, S., and Finlay, J.L. (1998) Myeloablative chemotherapy with autologous bone marrow rescue in young children with recurrent malignant brain tumors. J. Clin. Oncol. 16,2486 -2493.[Abstract]

Hoppe-Hirsch, E., Brunet, L., Laroussinie, F., Cinalli, G., Pierre-Kahn, A., Renier, D., Sainte-Rose, C., and Hirsch, J.F. (1995) Intellectual outcome in children with malignant tumors of the posterior fossa: Influence of the field of irradiation and quality of surgery. Childs Nerv. Syst. 11,340 -346.[CrossRef][ISI][Medline]

Jakacki, R.I., Zeltzer, P.M., Boyett, J.M., Albright, A.L., Allen, J.C., Geyer, J.R., Rorke, L.B., Stanley, P., Stevens, K.R., Wisoff J., McGuire-Cullen, P., Milstein, J., Packer, R.J., Finlay, J.L. (1995) Survival and prognostic factors following radiation and/or chemotherapy for primitive neuroectodermal tumors of the pineal region in infants and children: A report of the Children's Cancer Group. J. Clin. Oncol. 13,1377 -1383.[Abstract]

Jellinger, K., and Sunder-Plassman, M. (1973) Connatal intracranial tumors. Neuropadiatrie 4, 46-63.[Medline]

Kalifa, C., Raquin, M., Bouffet, E., Gentet, E.C., Doz, P., Chastagner, P., Perel, Y., McDowell, H., and the SFOP Brain Tumor Group (1995) Chemotherapy without irradiation (RT) in medulloblastoma patients younger than three. A prospective study by the French Society of Pediatric Oncology (SFOP). Med. Pediatr. Oncol. 25, 250. (Abstract)

Kühl, J., Beck, J., Bode, U., Deinlein, F., Gnekow, A., Graf, N., Havers, W., Kleihues, P., Niethammer, D., Riehm, H.J., Scheurlen, W., and Spar, H.J., for the German Pediatric Brain Tumor Study Group (1995) Delayed radiation therapy (RT) after postoperative chemotherapy (PCH) in children less than 3 years of age with medulloblasoma. Results of the trial HIT-SKK'87 and preliminary results of the pilot trial HIT-SKK'92. Med. Pediatr. Oncol. 25, 250. (Abstract)

Kun, L.E. (1997) Brain tumors: Challenges and directions. Pediatr. Clin. North Am. 44,907 -917.[Medline]

Lashford, L.S., Campbell, R.H., Gattamaneni, H.R., Robinson, K., Walker, D., and Bailey, C. (1996) An intensive multiagent chemotherapy regimen for brain tumours occurring in very young children. Arch. Dis. Child. 74,219 -223.[Abstract]

Mason, W.P., Grovas, A., Halpern, S., Dunkel, I.J., Garvin, J., Heller, G., Rosenblum, M., Gardner, S., Lyden, D., Sands, S., Puccetti, D., Lindsley, K., Merchant, T.E., O'Malley, B., Bayer, L., Petriccione, M.M., Allen, J., and Finlay, J.L. (1998a) Intensive chemotherapy and bone marrow rescue for young children with newly diagnosed malignant brain tumors. J. Clin. Oncol. 16,210 -221.[Abstract/Free Full Text]

Mason, W.P., Goldman, S., Yates, A.J., Boyett, J., Li, H., and Finlay, J.L. (1998b) Survival following intensive chemotherapy with bone marrow reconstitution for children with recurrent intracranial ependymoma—a report of the Children's Cancer Group. J. Neurooncol. 37,135 -143.[CrossRef][Medline]

Razzaq, A.A., and Cohen, A.R. (1997) Neoadjuvant chemotherapy for hypervascular malignant brain tumors of childhood. Pediatr. Neurosurg. 27,296 -303.[Medline]

Stiller, C.A., and Bunch, K.J. (1992) Brain and spinal tumours in children aged under two years: Incidence and survival in Britain, 1971-85. Br. J. Cancer 66 (Suppl. 18),S50 -S53.

Suc, E., Kalifa, C., Brauner, R., Habrand, J.L., Terrier-Lacombe, M.J., Vassal, G., and Lemerle, J. (1990) Brain tumours under the age of three. The price of survival. A retrospective study of 20 long-term survivors. Acta Neurochir. (Wien) 106, 93-98.[CrossRef][Medline]

Tomita, T., and McLone, D.G. (1985) Brain tumors during the first twenty-four months of life. Neurosurgery 17,913 -919.[Medline]

van Eys, J., Cangir, A., Coody, D., and Smith, B. (1985) MOPP regimen as primary chemotherapy for brain tumors in infants. J. Neurooncol. 3, 237-243.[CrossRef][Medline]

White, L., Kellie, S., Gray, E., Toogood, I., Waters, K., Lockwood, L., Macfarlane, S., and Johnston, H. (1998) Postoperative chemotherapy in children less than 4 years of age with malignant brain tumors: Promising initial response to a VETOPEC-based regimen. A study of the Australian and New Zealand Children's Cancer Study Group (ANZCCSG). J. Pediatr. Hematol. Oncol. 20,125 -130.[CrossRef][ISI][Medline]

White, L., Johnston, H., Jones, R., Mameghan, H., Nayanar, V., McWhirter, W., Kellie, S., Waters, K., and Toogood, I. (1993) Postoperative chemotherapy without radiation in young children with malignant non-astrocytic brain tumors. A report from the Australian and New Zealand Children's Cancer Study Group (ANZCCSG). Cancer Chemother. Pharmacol. 32,403 -406.[CrossRef][Medline]




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