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Symposium Genetic Classification and Treatment of Malignant Gliomas and Oligodendrogliomas |
Department of Neuro-Oncology and the Brain Tumor Center, M.D. Anderson Cancer Center, University of Texas, Houston, TX 77030
2 Address correspondence and reprint requests to Victor A. Levin, MD, Department of Neuro-Oncology-100, M.D. Anderson Cancer Center, University of Texas, 1515 Holcombe Boulevard, Houston, TX 77030.
Abstract
Over the past three decades, we have made great strides in the treatment of most, but not all, brain tumors. Dramatic advances have occurred in diagnostic imaging, neurosurgery, neuroanesthesia, radiotherapy, and chemotherapy for CNS tumors. Unfortunately, our progress has not yet met our expectations. Because of the infiltrative nature of most primary brain tumors, neurosurgery can never be expected to be curative for the majority of gliomas. Because infiltrative tumors interdigitate with normal brain cells and are not highly sensitive to irradiation, one cannot expect radiotherapy to be curative without serious damage to normal brain cells. The hope for a cure, then, rests with chemotherapy. Those who administer chemotherapy to patients with CNS tumors fully expect that, in time, long-term survival and, ultimately, the cure will become an everyday reality. To achieve that reality, however, new treatment concepts and drugs are needed.
References
Allison, R.R., Schulsinger, A., Vongtama, V., Barry, T., and Shin, K.H. (1997) Radiation and chemotherapy improve outcome in oligodendroglioma. Int. J. Radiat. Oncol. Biol. Phys. 37,399 -403.[CrossRef][ISI][Medline]
Ameri, A., Poisson, M., Chauveinc, L., Chen, Q.M., and Delattre, J.Y. (1997) Treatment of recurrent malignant supratentorial gliomas with the association of carboplatin and etoposide: A phase II study. J. Neurooncol. 32,155 -160.[CrossRef][Medline]
Berger, M.S., Leibel, S.A., Bruner, J.M., Finlay, J.L., and Levin, V.A. (1995) Primary central nervous system tumors of the supratentorial compartment. In: Levin, V.A. (Ed.), Cancer in the Nervous System. New York:Churchill Livingstone. pp.57 -125.
Boiardi, A., Silvani, A., Milanesi, I., Botturi, M., and Broggi, G. (1992) Carboplatin combined with carmustine and etoposide in the treatment of glioblastoma. Ital. J. Neurol. Sci. 13,717 -722.[CrossRef][ISI][Medline]
Brandes, A.A., Scelzi, E., Zampieri, P., Rigon, A., Rotilio, A., Amista, P., Berti, F., and Fiorentino, M.V. (1997) Phase II trial with BCNU plus alpha-interferon in patients with recurrent high-grade gliomas. Am. J. Clin. Oncol. 20,364 -367.[CrossRef][ISI][Medline]
Brandes, A.A., Rigon, A., Zampieri, P., Ermani, M., Carollo, C., Altavilla, G., Turazzi, S., Chierichetti, F., and Fiorentino, M.V. (1998) Carboplatin and teniposide concurrent with radiotherapy in patients with glioblastoma multiforme — A phase II study. Cancer 82,355 -361.[CrossRef][ISI][Medline]
Buckner, J.C., Brown, L.D., Cascino, T.L., Gerstner, J.B., Krook, J.E., Westberg, M.W., Wiesenfeld, M., O'Fallon, J.R., and Scheithauer, B. (1990) Phase II evaluation of infusional etoposide and cisplatin in patients with recurrent astrocytoma. J. Neurooncol. 9, 249-254.[Medline]
Buckner, J.C., Brown, L.D., Kugler, J.W., Cascino, T.L., Krook, J.E., Mailliard, J.A., Kardinal, C.G., Tschetter, L.K., O'Fallon, J.R., and Scheithauer, B.W. (1995) Phase II evaluation of recombinant interferon alpha and BCNU in recurrent glioma. J. Neurosurg. 82,430 -435.[ISI][Medline]
Buckner, J.C., Burch, P.A., Cascino, T.L., Ofallon, J.R., and Scheithauer, B.W. (1998) Phase II trial of recombinant interferon-alpha-2a and e'ornithine in patients with recurrent glioma. J. Neurooncol. 36,65 -70.[CrossRef][Medline]
Cairncross, G., Macdonald, D., Ludwin, S., Lee, D., Cascino, T.,
Buckner, J., Fulton, D., Dropcho, E., Stewart, D., and Schold, C.J.
(1994) Chemotherapy for anaplastic oligodendroglioma. National
Cancer Institute of Canada Clinical Trials Group. J. Clin.
Oncol. 12,2013
-2021.
Chamberlain, M.C. (1997) Recurrent supratentorial malignant gliomas in children. Long-term salvage therapy with oral etoposide. Arch. Neurol. 54,554 -558.[Abstract]
Chamberlain, M.C., and Kormanik, P. (1995) Salvage
chemotherapy with paclitaxel for recurrent primary brain tumors. J.
Clin. Oncol. 13,2066
-2071.
Chamberlain, M.C., and Kormanik, P.A. (1997) Salvage
chemotherapy with paclitaxel for recurrent oligodendrogliomas. J.
Clin. Oncol. 15,3427
-3432.
Chang, S., Schold, C., Spence, A., Berger, M., McAllister, L., Mehta, M., Gilbert, M.R., Fulton, D., and Prados, M. (1996) Phase I/II study of paclitaxel chemotherapy for recurrent malignant glioma: Preliminary report. North American Brain Tumor Consortium. Proc. Annu. Meet. Am. Soc. Clin. Oncol. 15, A276. (Abstract)
Chang, S.M., Barker, F.G., Huhn, S.L., Nicholas, M.K., Page, M., Rabbitt, J., and Prados, M.D. (1998) High dose oral tamoxifen and subcutaneous interferon alpha-2a for recurrent glioma. J. Neurooncol. 37,169 -176.[CrossRef][Medline]
Chauveinc, L., Sola-Martinez, M.T., Martin-Duverneuil, M., Mazeron, J.J., Faillot, T., Cornu, P., Capelle, L., Delattre, J.Y., Poisson, M., Baillet, F., and Chiras, J. (1996) Intra-arterial chemotherapy with ACNU and radiotherapy in inoperable malignant gliomas. J. Neurooncol. 27,141 -147.[Medline]
Choucair, A.K., Levin, V.A., Gutin, P.H., Davis, R.L., Silver, P., Edwards, M.S., and Wilson, C.B. (1986) Development of multiple lesions during radiation therapy and chemotherapy in patients with gliomas. J. Neurosurg. 65,654 -658.[ISI][Medline]
Corn, B.W., Yousem, D.M., Scott, C.B., Rotman, M., Asbell, S.O., Nelson, D.F., Martin, L., and Curran, W.J., Jr. (1994) White matter changes are correlated significantly with radiation dose. Observations from a randomized dose-escalation trial for malignant glioma. (Radiation Therapy Oncology Group 83-02) Cancer 74,2828 -2835.[CrossRef][ISI][Medline]
Couldwell, W.T., Hinton, D.R., Surnock, A.A., DeGiorgio, C.M., Weiner, L.P., Apuzzo, M.L., Masri, N.L., Law, R.E., and Weiss, M.H. (1996) Treatment of recurrent malignant gliomas with chronic oral high-dose tamoxifen. Clin. Cancer Res. 2, 619-622.[Abstract]
Dolan, M.E., Mitchell, R.B., Mummert, C., Moschel, R.C., and Pegg,
A.E. (1991) Effect of O6-benzylguanine analogues on sensitivity
of human tumor cells to the cytotoxic effects of alkylating agents.
Cancer Res. 51,3367
-3372.
Dolan, M.E., Pegg, A.E., Moschel, R.C., Vishnuvajjala, B.R., Flora, K.P., Grever, M.R., and Friedman, H.S. (1994) Biodistribution of O6-benzylguanine and its effectiveness against human brain tumor xenografts when given in polyethylene glycol or cremophor-EL. Cancer Chemother. Pharmacol. 35,121 -126.[ISI][Medline]
Dropcho, E.J., Rosenfeld, S.S., Vitek, J., Guthrie, B.L., and Morawetz, R.B. (1998) Phase II study of intracarotid or selective intracerebral infusion of cisplatin for treatment of recurrent anaplastic gliomas. J. Neurooncol. 36,191 -198.[CrossRef][Medline]
Dunkel, I.J., O'Malley, B., and Finlay, J.L. (1996) Is there a role for high-dose chemotherapy with stem cell rescue for brain stem tumors of childhood? Pediatr. Neurosurg. 24,263 -266.
Farkkila, M., Jaaskelainen, J., Kallio, M., Blomstedt, G., Raininko, R., Virkkunen, P., Paetau, A., Sarelin, H., and Mantyla, M. (1994) Randomised, controlled study of intratumoral recombinant gamma-interferon treatment in newly diagnosed glioblastoma. Brit. J. Cancer 70,138 -141.[ISI][Medline]
Fernandez-Hidalgo, O.A., Vanaclocha, V., Vieitez, J.M., Aristu, J.J., Rebollo, J., Gurpide, A., Aramendia, J.M., Moreno-Palanques, R., Martin-Algarra, S., Subira, M.L., and Brugarolas, A. (1996) High-dose BCNU and autologous progenitor cell transplantation given with intra-arterial cisplatinum and simultaneous radiotherapy in the treatment of high-grade gliomas: Benefit for selected patients. Bone Marrow Transplant. 18,143 -149.[ISI][Medline]
Fine, H.A., Loef'er, J.S., Kyritsis, A., Wen, P., Black, P.M., Levin, V.A., Graham, S., and Yung, W.A. (1997) A phase II trial of the anti-angiogenic agent, thalidomide, in patients with recurrent high-grade gliomas. Proc. Annu. Meet. Am. Soc. Clin. Oncol. 16,A1372 . (Abstract)
Finlay, J.L. (1996) The role of high-dose chemotherapy and stem cell rescue in the treatment of malignant brain tumors. Bone Marrow Transplant. 18 (suppl 3),S1 -S5.
Finlay, J.L., August, C., Packer, R., Zimmerman, R., Sutton, L., Freid, A., Rorke, L., Bayever, E., Kamani, N., and Kramer, E. (1990) High-dose multi-agent chemotherapy followed by bone marrow `rescue' for malignant astrocytomas of childhood and adolescence. J. Neurooncol. 9,239 -248.[CrossRef][Medline]
Finlay, J.L., Boyett, J.M., Yates, A.J., Wisoff, J.H., Milstein,
J.M., Geyer, J.R., Bertolone, S.J., McGuire, P., Cherlow, J.M., and Tefft, M.
(1995) Randomized phase III trial in childhood high-grade
astrocytoma comparing vincristine, lomustine, and prednisone with the
eight-drugs-in-1-day regimen. Childrens Cancer Group. J. Clin.
Oncol. 13,112
-123.
Finlay, J.L., Goldman, S., Wong, M.C., Cairo, M., Garvin, J., August, C., Cohen, B.H., Stanley, P., Zimmerman, R.A., Bostrom, B., Geyer, J.R., Harris, R.E., Sanders, J., Yates, A.J., Boyett, J.M., and Packer, R.J. (1996) Pilot study of high-dose thiotepa and etoposide with autologous bone marrow rescue in children and young adults with recurrent CNS tumors. The Children's Cancer Group. J. Clin. Oncol. 14,2495 -2503.[Abstract]
Fulton, D., Urtasun, R., and Forsyth, P. (1996) Phase II study of prolonged oral therapy with etoposide (VP16) for patients with recurrent malignant glioma. J. Neurooncol. 27,149 -155.[Medline]
Gajjar, A., Heideman, R.L., Kovnar, E.H., Langston, J.A., Sanford, R.A., Douglass, E.C., Jenkins, J.J., Horowitz, M.E., and Kun, L.E. (1993) Response of pediatric low grade gliomas to chemotherapy. Pediatr. Neurosurg. 19,113 -118.[ISI][Medline]
Gregor, A., Rampling, R., Aapro, M., Malmstrom, P., Whittle, I.R., Rye, R., Stewart, D., Sellar, R., Demierre, B., and Ironside, J.W. (1992) Phase II study of tauromustine in malignant glioma. Eur. J. Cancer 28A,1959 -1962.[CrossRef]
Grossman, S.A., Wharam, M., Sheidler, V., Kleinberg, L., Zeltzman,
M., Yue, N., and Piantadosi, S. (1997) Phase II study of
continuous infusion carmustine and cisplatin followed by cranial irradiation
in adults with newly diagnosed high-grade astrocytoma. J. Clin.
Oncol. 15,2596
-2603.
Hammack, J., Shaw, E., Ivnik, R., Arusell, R., Novotny, P., and O'Fallon, J. (1995) Neurocognitive function in patients receiving radiation therapy (RT) for supratentorial low grade glioma (LGG): A North Central Cancer Treatment Group (NCCTG) prospective study. Proc. Annu. Meet. Am. Soc. Clin. Oncol. 14, A299. (Abstract)
Hariharan, S., Stuebgen, P., Boyett, J.M., Yates, A.J., and Finlay, J.L. (1996) Anaplastic mixed gliomas in childhood: Results from the Children's Cancer Group Study, CCG-945. Proc. Annu. Meet. Am. Soc. Clin. Oncol. 15,A1471 . (Abstract)
Heideman, R.L., Kuttesch, J.J., Gajjar, A.J., Walter, A.W., Jenkins, J.J., Li, Y., Sanford, R.A., and Kun, L.E. (1997) Supratentorial malignant gliomas in childhood: A single institution perspective. Cancer 80,497 -504.[CrossRef][ISI][Medline]
Hellman, R., Neuberg, D.S., Wagner, H., Gunnet, M., Robins, H.I., Karp, D., Flynn, P., and Adams, G. (1998) A therapeutic trial of radiation therapy with vincristine, etoposide, and procarbazine (VVP) in high grade intracranial gliomas—An Eastern Cooperative Oncology Group study (E2392). J. Neurooncol. 37, 55-62.[CrossRef][Medline]
Hiesiger, E.M., Green, S.B., Shapiro, W.R., Burger, P.C., Selker, R.G., Mahaley, M.S., Jr., Ransohoff, J., VanGilder, J.C., Mealey, J.J., and Robertson, J.T. (1995) Results of a randomized trial comparing intra-arterial cisplatin and intravenous PCNU for the treatment of primary brain tumors in adults: Brain Tumor Cooperative Group trial 8420A. J. Neurooncol. 25,143 -154.[CrossRef][Medline]
Hildebrand, J., Dewitte, O., and Sahmoud, T. (1998) Response of recurrent glioblastoma and anaplastic astrocytoma to dibromodulcitol, BCNU and procarbazine - A phase-II study. J. Neurooncol. 37,155 -160.[CrossRef][Medline]
Ikeda, J., Aida, T., Sawamura, Y., Abe, H., Kaneko, S., Kashiwaba, T., Kawamoto, T., Mitsumori, K., and Saitoh, H. (1996) Phase II study of DTIC, ACNU, and vincristine combination chemotherapy for supratentorial malignant astrocytomas. Neurol. Med. Chir. 36,555 -558.
Iwadate, Y., Namba, H., and Sueyoshi, K. (1995) Intra-arterial ACNU and cisplatin chemotherapy for the treatment of glioblastoma multiforme. Neurol. Med. Chir. 35,598 -603.
Jason, G.W., Pajurkova, E.M., Taenzer, P.A., and Bultz, B.D. (1997) Acute effects on neuropsychological function and quality of life by high-dose multiple daily fractionated radiotherapy for malignant astrocytomas: Assessing the tolerability of a new radiotherapy regimen. Psycho-Oncology 6,151 -157.[CrossRef][Medline]
Jeremic, B., Grujicic, D., Jevremovic, S., Stanisavljevic, B., Milojevic, L., Djuric, L., and Mijatovic, L. (1992) Carboplatin and etoposide chemotherapy regimen for recurrent malignant glioma: A phase II study. J. Clin. Oncol. 10,1074 -1077.[Abstract]
Kaba, S.E., Kyritsis, A.P., Conrad, C., Gleason, M.J., Newman, R., Levin, V.A., and Yung, W.K. (1997) The treatment of recurrent cerebral gliomas with all-trans-retinoic acid (tretinoin). J. Neurooncol. 34,145 -151.[CrossRef][Medline]
Kirby, S., Macdonald, D., Fisher, B., Gaspar, L., and Cairncross, G. (1996) Pre-radiation chemotherapy for malignant glioma in adults. Can. J. Neurol. Sci. 23,123 -127.[ISI][Medline]
Knerich, R., Adinolfi, D., Giunta, F., Buoncristiani, P., Gaetani, P., Assietti, R., D'Ettorre, F., Butti, G., and Schiffer, D. (1990) Single versus multiple drug therapy in the combined treatment of malignant gliomas. A multicenter study. J. Neurosurg. Sci. 34,251 -255.[Medline]
Kurpad, S.N., Dolan, M.E., McLendon, R.E., Archer, G.E., Moschel, R.C., Pegg, A.E., Bigner, D.D., and Friedman, H.S. (1997) Intraarterial O6-benzylguanine enables the specific therapy of nitrosourea-resistant intracranial human glioma xenografts in athymic rats with 1,3-bis(2-chloroethyl)-1-nitrosourea. Cancer Chemother. Pharmacol. 39,307 -316.[CrossRef][ISI][Medline]
Kyritsis, A.P., Yung, W.K., Bruner, J., Gleason, M.J., and Levin, V.A. (1993) The treatment of anaplastic oligodendrogliomas and mixed gliomas. Neurosurgery 32,365 -370.[ISI][Medline]
Kyritsis, A.P., Yung, W.K., Jaeckle, K.A., Bruner, J., Gleason, M.J., Ictech, S.E., Flowers, A., and Levin, V.A. (1996) Combination of 6-thioguanine, procarbazine, lomustine, and hydroxyurea for patients with recurrent malignant gliomas. Neurosurgery 39,921 -926.[CrossRef][ISI][Medline]
Kyritsis, A., Newlands, E.S., Brock, C.S.G., Jaeckle, K., Levin, V., Bower, M., Evans, H., Dane, G., DeWitte, M., and Yung, W. (1997) Phase II trial of topotecan (T) as a continuous intravenous infusion (CIV) in patients (pts) with high-grade gliomas. Proc. Annu. Meet. Am. Soc. Clin. Oncol. 16, A1404. (Abstract)
Levin, V.A. (1980) Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability. J. Med. Chem. 23,682 -684.[CrossRef][ISI][Medline]
Levin, V.A., and Prados, M.D. (1992) Treatment of
recurrent gliomas and metastatic brain tumors with a polydrug protocol
designed to combat nitrosourea resistance. J. Clin.
Oncol. 10,766
-771.
Levin, V.A., Landahl, H.D., and Freeman-Dove, M.A. (1976) The application of brain capillary permeability coefficient measurements to pathological conditions and the selection of agents which cross the blood-brain barrier. J. Pharmacokinet. Biopharm. 4,499 -519.[CrossRef][ISI][Medline]
Levin, V.A., Silver, P., Hannigan, J., Wara, W.M., Gutin, P.H., Davis, R.L., and Wilson, C.B. (1990) Superiority of post-radiotherapy adjuvant chemotherapy with CCNU, procarbazine, and vincristine (PCV) over BCNU for anaplastic gliomas: NCOG 6G61 final report. Int. J. Radiat. Oncol. Biol. Phys. 18,321 -324.[ISI][Medline]
Levin, V.A., Prados, M.D., Yung, W.K., Gleason, M.J., Ictech, S.,
and Malec, M. (1992) Treatment of recurrent gliomas with
e'ornithine. J. Nat. Cancer Inst.
84,1432
-1437.
Levin, V.A., Maor, M.H., Thall, P.F., Yung, W.K., Bruner, J., Sawaya, R., Kyritsis, A.P., Leeds, N., Woo, S., and Rodriguez, L. (1995a) Phase II study of accelerated fractionation radiation therapy with carboplatin followed by vincristine chemotherapy for the treatment of glioblastoma multiforme. Int. J. Radiat. Onco. Biol. Phys. 33,357 -364.
Levin, V.A., Prados, M.D., Wara, W.M., Davis, R.L., Gutin, P.H., Phillips, T.L., Lamborn, K., and Wilson, C.B. (1995b) Radiation therapy and bromodeoxyuridine chemotherapy followed by procarbazine, lomustine, and vincristine for the treatment of anaplastic gliomas. Int. J. Radiat. Oncol. Biol. Phys. 32, 75-83.[CrossRef][ISI][Medline]
Levin, V.A., Leibel, S.A., and Gutin, P.H. (1997) Neoplasms of the central nervous system. In: DeVita, V.T., Jr., Hellman, S., and Rosenberg, S.A. (Eds.), Cancer: Principles and Practice of Oncology. Philadelphia: Lippincott-Raven. pp.2022 -2082.
Malkin, M.G., Green, S.B., Byar, D.P., Strike, T.A., Burger, P.C., Vogel, F.S., Pistenmaa, D.A., Mahaley, M.S.J., Ransohoff, J., and Shapiro, W.R. (1994) Superiority of PCNU over AZQ in the treatment of primary brain tumors: Results of a prospective randomized trial (81-20) by the Brain Tumor Study Group. J. Neurooncol. 22, 55-65.[CrossRef][Medline]
Malkin, M.G., Mason, W.P., Lieberman, F.S., Shawver, L.K., and Hannah, A.L. (1996) A phase I and pharmacokinetic study of SU101, a novel signal transduction inhibitor in patients with recurrent malignant glioma. Proc. Annu. Meet. Am. Soc. Clin. Oncol. 15, A1573. (Abstract)
Mason, W., Louis, D.N., and Cairncross, J.G. (1997)
Chemosensitive gliomas in adults: Which ones and why? J. Clin.
Oncol. 15,3423
-3426.
Mastronardi, L., Puzzilli, F., Couldwell, W.T., Farah, J.O., and Lunardi, P. (1998) Tamoxifen and carboplatin combination treatment of high-grade gliomas—Results of a clinical trial on newly diagnosed patients. J. Neurooncol. 38, 59-68.[CrossRef][Medline]
Mineura, K., Izumi, I., Kuwahara, N., and Kowada, M. (1994) O6-methylguanine-DNA methyltransferase activity in cerebral gliomas. A guidance for nitrosourea treatment? Acta. Oncol. 33,29 -32.[ISI][Medline]
New, P., Vokes, E., Rogers, L., Bazan, C., Hohneker, J., Eble, M., and Vilk, P. (1997) Long-term response to crisnatol mesylate in patients with glioma. Invest. New Drugs 15,343 -352.[CrossRef][ISI][Medline]
Newton, H.B., Junck, L., Bromberg, J., Page, M.A., and Greenberg,
H.S. (1990) Procarbazine chemotherapy in the treatment of
recurrent malignant astrocytomas after radiation and nitrosourea failure.
Neurology 40,1743
-1746.
Nishimura, R., Takahashi, M., Morishita, S., Sumi, M., Uozumi, H., and Sakamoto, Y. (1992) MR imaging of late radiation brain injury. Radiat. Med. 10,101 -108.[Medline]
Packer, R.J., Ater, J., Allen, J., Phillips, P., Geyer, R., Nicholson, H.S., Jakacki, Kurczynski, E., Needle, M., Finlay, J., Reaman, G., and Boyett, J.M. (1997) Carboplatin and vincristine chemotherapy for children with newly diagnosed progressive low-grade gliomas. J. Neurosurg. 86,747 -754.[ISI][Medline]
Peterson, K., Paleologos, N., Forsyth, P., Macdonald, D.R., and Cairncross, J.G. (1996) Salvage chemotherapy for oligodendroglioma. J. Neurosurg. 85,597 -601.[ISI][Medline]
Petronio, J., Edwards, M.S., Prados, M., Freyberger, S., Rabbitt, J., Silver, P., and Levin, V.A. (1991) Management of chiasmal and hypothalamic gliomas of infancy and childhood with chemotherapy. J. Neurosurg. 74,701 -708.[CrossRef][ISI][Medline]
Phillips, T.L., Levin, V.A., Ahn, D.K., Gutin, P.H., Davis, R.L., Wilson, C.B., Prados, M.D., Wara, W.M., and Flam, M.S. (1991) Evaluation of bromodeoxyuridine in glioblastoma multiforme: A Northern California Cancer Center Phase II study. Int. J. Radiat. Oncol. Biol. Phys. 21,709 -714.[ISI][Medline]
Pons, M.A., Finlay, J.L., Walker, R.W., Puccetti, D., Packer, R.J. and McElwain, M. (1992) Chemotherapy with vincristine (VCR) and etoposide (VP-16) in children with low-grade astrocytoma. J. Neurooncol. 14,151 -158.[Medline]
Postma, T.J., Vangroeningen, C.J., Witjes, R.M., Weerts, J.E., Kralendonk, J.H., and Heimans, J.J. (1998) Neurotoxicity of combination chemotherapy with procarbazine, ccnu and vincristine (PCV) for recurrent glioma. J. Neurooncol. 38, 69-75.[CrossRef][Medline]
Prados, M.D., Edwards, M.S., Rabbitt, J., Lamborn, K., Davis, R.L., and Levin, V.A. (1997) Treatment of pediatric low-grade gliomas with a nitrosourea-based multiagent chemotherapy regimen. J. Neurooncol. 32,235 -241.[CrossRef][Medline]
Prados, M.D., Scott, C.B., Rotman, M., Rubin, P., Murray, K., Sause, W., Asbell, S., Comis, R., Curran, W., Nelson, J., Davis, R.L., Levin, V.A., Lamborn, K., and Phillips, T.L. (1998a) In'uence of bromodeoxyuridine radiosensitization on malignant glioma patient survival: A retrospective comparison of survival data from the Northern California Oncology Group (NCOG) and Radiation Therapy Oncology Group (RTOG) trials for glioblastoma multiforme and anaplastic astrocytoma. Int. J. Radiat. Oncol. Biol. Phys. 40,653 -659.[CrossRef][ISI][Medline]
Prados, M.D., Larson, D.A., Lamborn, K., Mcdermott, M.W., Sneed, P.K., Wara, W.M., Chang, S.M., Mack, E.E., Krouwer, H.G., Chandler, K.L., Warnick, R.E., Davis, R.L., Rabbitt, J.E., Malec, M., Levin, V.A., Gutin, P.H., Phillips, T.L., and Wilson, C.B. (1998b) Radiation therapy and hydroxyurea followed by the combination of 6-thioguanine and BCNU for the treatment of primary malignant brain tumors. Int. J. Radiat. Oncol. Biol. Phys. 40,57 -63.[CrossRef][ISI][Medline]
Rodriguez, L.A., Prados, M., Silver, P., and Levin, V.A. (1989) Reevaluation of procarbazine for the treatment of recurrent malignant central nervous system tumors. Cancer 64,2420 -2423.[CrossRef][ISI][Medline]
Scheibel, R.S., Meyers, C.A., and Levin, V.A. (1996) Cognitive dysfunction following surgery for intracerebral glioma: In'uence of histopathology, lesion location, and treatment. J. Neurooncol. 30,61 -69.[CrossRef][Medline]
Schold, S.C., Jr., Herndon, J.E., Burger, P.C., Halperin, E.C., Vick, N.A., Cairncross, J.G., Macdonald, D.R., Dropcho, E.J., Morawetz, R., Bigner, D.D., and Mahaley, M., Jr. (1993) Randomized comparison of diaziquone and carmustine in the treatment of adults with anaplastic glioma. J. Clin. Oncol. 11, 77-83.[Abstract]
Schold, S.C., Jr., Kokkinakis, D.M., Rudy, J.L., Moschel, R.C., and
Pegg, A.E. (1996) Treatment of human brain tumor xenografts with
O6-benzyl-2'-deoxyguanosine and BCNU. Cancer Res.
56,2076
-2081.
Silvani, A., Salmaggi, A., Pozzi, A., Fariselli, L., Franzini, A., and Boiardi, A. (1995) Effectiveness of early chemotherapy treatment in anaplastic astrocytoma patients. Tumori 81,424 -428.[ISI][Medline]
Van Tassel, P., Bruner, J.M., Maor, M.H., Leeds, N.E., Gleason, M.J., Yung, W.K., and Levin, V.A. (1995) MR of toxic effects of accelerated fractionation radiation therapy and carboplatin chemotherapy for malignant gliomas. Am. J. Neurorad. 16,715 -726.[Abstract]
Wacker, M.R., Hoshino, T., Ahn, D.K., Davis, R.L., and Prados, M.D. (1994) The prognostic implications of histologic classification and bromodeoxyuridine labeling index of mixed gliomas. J. Neurooncol. 19,113 -122.[CrossRef][Medline]
Warnick, R.E., Prados, M.D., Mack, E.E., Chandler, K.L., Doz, F., Rabbitt, J.E., and Malec, M.K. (1994) A phase II study of intravenous carboplatin for the treatment of recurrent gliomas. J. Neurooncol. 19,69 -74.[CrossRef][Medline]
Yung, W.K., Mechtler, L., and Gleason, M.J. (1991a) Intravenous carboplatin for recurrent malignant glioma: A phase II study. J. Clin. Oncol. 9,860 -864.[Abstract]
Yung, W.K., Prados, M., Levin, V.A., Fetell, M.R., Bennett, J.,
Mahaley, M.S., Salcman, M., and Etcubanas, E. (1991b) Intravenous
recombinant interferon beta in patients with recurrent malignant gliomas: A
phase I/II study. J. Clin. Oncol.
9,1945
-1949.
Yung, W.K., Janus, T.J., Maor, M., and Feun, L.G. (1992) Adjuvant chemotherapy with carmustine and cisplatin for patients with malignant gliomas. J. Neurooncol. 12,131 -135.[Medline]
Yung, W.K., Levin, V.A., Kyritsis, A., Jaeckle, K., Vaickus, L., and Peterson, P. (1994) A phase II study of rIFN-beta +/-cRA in recurrent gliomas. J. Immunother. 16, 246. (Abstract)
Yung, W.K.A., Kyritsis, A.P., Gleason, M.J., and Levin, V.A. (1996) The treatment of recurrent malignant gliomas with high dose 13-cis retinoic acid. Clin. Cancer Res. 2,1931 -1935.[Abstract]
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