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Symposium Genetic Classification and Treatment of Malignant Gliomas and Oligodendrogliomas |
Department of Pathology, Duke University Medical Center, Durham, NC 27710
2 Address correspondence and reprint requests to Sandra H. Bigner, MD, Duke University Medical Center, Box 3712, Durham, NC 27710.
Abstract
Morphologic criteria for diagnosing oligodendrogliomas and for classifying them as well-differentiated (World Health Organization grade II) and anaplastic (World Health Organization grade III) are well recognized. Nevertheless, applying these guidelines to specific cases often reveals discrepancies among different observers. In addition, whether a given tumor also contains an astrocytic component may be debatable. Loss of heterozygosity studies have demonstrated that oligodendroglial neoplasms have a high incidence of loss of the 1p and 19q chromosomal arms. Although loss of heterozygosity for portions of 19q are sometimes seen in astrocytic neoplasms, these tumors seldom show complete loss of 19q accompanied by loss of 1p. Loss of 9p or homozygous deletion of the CDKN2 gene or both are associated with anaplastic oligodendrogliomas, whereas loss of 17p or TP53 gene mutations or both are frequent in astrocytomas, but rare in oligodendrogliomas. These observations suggest that molecular genetic parameters could provide an objective, reproducible framework for classifying oligodendroglial neoplasms.
References
Bailey, P., and Bucy, P.C. (1929) Oligodendrogliomas of the brain. J. Pathol. Bacteriol. 32,735 -751.[CrossRef]
Bailey, P., and Cushing, H.A. (1926) A classification of the gliomata. In:Classification of the Tumors of the Glioma Group on a Histogenetic Basis with a Correlated Study of Prognosis. Philadelphia: Lippincott. pp. 53-95.
Bardosi, A., Dimitri, T., and Gabius, H.J. (1988) Endogenous carbohydrate-binding proteins in oligodendrogliomas. A histochemical study. Acta. Neuropathol. 76, 55-61.[CrossRef][Medline]
Bello, M.J., Vaquero, J., de Campos, J.M., Kusak, M.E., Sarasa, J.L., Saez, J., Pestafia, A., Rey, J.A. (1994) Molecular analysis of chromosome 1 abnormalities in human gliomas reveals frequent loss of 1p in oligodendroglial tumors. Intl. J. Cancer 57,172 -175.[ISI][Medline]
Bello, M.J., Leone, P.E., Nebreda, P., de Campos, J.M., Kusak, M.E., Vaquero, J., Sarasa, J.L., Garcia-Miguel, P., Queizan, A., Hernández-Moneo, J.L., Pestana, A., and Rey, J.A. (1995) Allelic status of chromosome 1 in neoplasms of the nervous system. Cancer Genet. Cytogenet. 83,160 -164.[CrossRef][ISI][Medline]
Bruner, J.M. (1987) Oligodendroglioma: Diagnosis and prognosis. Semin. Diagn. Pathol. 4, 251-261.[ISI][Medline]
Burger, P.C., Rawlings, C.E., Cox, E.B., McLendon, R.E., Schold, S.C., Jr., and Bullard, D.E. (1987) Clinicopathologic correlations in the oligodendroglioma. Cancer 59,1345 -1352.[CrossRef][ISI][Medline]
Cairncross, J.G., Ueki, K., Zlatescu, M.C., Lisle, D.K.,
Finkelstein, D.M., Hammond, R.R., Silver, J.S., Stark, P.C., Macdonald, D.R.,
Ino, Y., Ramsay, D.A., and Louis, D.N. (1998) Specific genetic
predictors of chemotherapeutic response and survival in patients with
anaplastic oligodendrogiomas. J. Natl. Cancer Inst.
90,1473
-1479.
Choi, B.H., and Kim, R.C. (1984) Expression of glial
fibrillary acidic protein in immature oligodendroglia.
Science 223,407
-409.
Choi, B.H., and Lapham, L.W. (1978) Radial glia in the human fetal cerebrum: A combined golgi, immuno'uorescent and electron microscopic study. Brain Res. 148,295 -311.[CrossRef][ISI][Medline]
Choi, B.H., Kim, R.C., and Lapham, L.W. (1983) Do radial glia give rise to both astroglial and oligodendroglial cells? Brain Res. 284,119 -135.
Coons, S.W., Johnson, P.C., and Pearl, D.K. (1997) The prognostic significance of Ki-67 labeling indices for oligodendrogliomas. Neurosurgery 41,878 -885.[CrossRef][ISI][Medline]
Cruz-Sanchez, F.F., Rossi, M.L., Buller, J.R., Carboni, P., Jr., Fineron, P.W., and Coakham, H.B. (1991) Oligodendrogliomas: A clinical, histological, immunocytochemical and lectin-binding study. Histopathology 19,361 -367.[ISI][Medline]
Daumas-Duport, C., Monsaigneon, V., Blond, S., Munari, C., Musolino, A., Chodkiewicz, J.P., and Missir, O. (1987) Serial stereotactic biopsies and CT scan in gliomas: Correlative study in 100 astrocytomas, oligoastrocytomas and oligodendrocytomas. J. Neurooncol. 4,317 -328.[Medline]
Dehghani, J., Schachenmayr, W., Laun, A., and Korf, H. (1998) Prognostic implication of histopathological, immunohistochemical and clinical features of oligodendrogliomas: A study of 89 cases. Acta. Neuropathol. 96,493 -504.
Earnest, F., III, Kernohan, J.W., and Craig, W.M. (1950) Oligodendrogliomas. Review of 200 cases. Arch. Neurol. Psychiatry 63,964 -976.[ISI][Medline]
Kimura, T., Budka, H., and Soler-Federsppiel, S. (1986) An immunocytochemical comparison of the glia-associated proteins glial fibrillary acidic protein (GFAP) and S-100 protein (S100P) in human brain tumours. Clin. Neuropathol. 5, 21-27.[ISI][Medline]
Kleihues, P., Burger, P.C., and Scheithauer, B.W. (1993) Histological Typing of Tumours of the Central Nervous System, 2nd edition. New York: Springer-Verlag. pp.1 -105.
Kraus, J.A., Koopmann, J., Kaskel, P., Maintz, D., Brandner, S., Schramm, J., Louis, D.N., Wiestler, O.D., and von Deimling, A. (1995) Shared allelic losses on chromosomes 1p and 19q suggest a common origin of oligodendroglioma and oligoastrocytoma. J. Neuropathol. Exp. Neurol. 54,91 -95.[ISI][Medline]
Kros, J.M., Van Eden, C.G., Stefanko, S.Z., Waayer-Van Batenburg, M., and van der Kwast, T.H. (1990) Prognostic implications of glial fibrillary acidic protein containing cell types in oligodendrogliomas. Cancer 66,1204 -1212.[CrossRef][ISI][Medline]
Kros, J.M., de Jong, A.A.W., and van der Kwast, T.H. (1992) Ultrastructural characterization of transitional cells in oligodendrogliomas. J. Neuropathol. Exp. Neurol. 51,186 -193.[ISI][Medline]
Kros, J.M., Hop, W.C., Godschalk, J.J.C.I., and Krishmadath, K.K. (1996) Prognostic value of the proliferation-related antigen Ki-67 in oligodendrogliomas. Cancer 78,1107 -1113.[CrossRef][ISI][Medline]
Maintz, D., Fiedler, K., Koopmann, J., Rollbrocker, B., Nechev, S., Lenartz, D., Stangl, A.P., Louis, D.N., Schramm, J., Wiestler, O.D., and von Deimling, A. (1997) Molecular genetic evidence for subtypes of oligoastrocytomas. J. Neuropathol. Exp. Neurol. 56,1098 -1104.[ISI][Medline]
Matthews, M.R., Rasheed, B.K.A., McLendon, M.E., Wikstrand, C.J., Bigner, D.D., and Bigner, S.H. (1998) Molecular and immunohistologic (IHC) studies on oligodendroglial (O) tumors. J. Neuropathol. Exp. Neurol. 57,473 . (Abstract)
Mørk, S.J., Lindegaard, K.-F., Halvorsen, T.B., Lehmann, E.H., Solgaard, T., Hatlevoli, R., Harvei, S., and Ganz, J. (1985) Oligodendroglioma: Incidence and biological behavior in a defined population. J. Neurosurg. 63,881 -889.[ISI][Medline]
Mørk, S.J., Halvorsen, T.B., Lindegaard, K.-F., and Eide, G.E. (1986) Oligodendroglioma. Histologic evaluation and prognosis. J. Neuropathol. Exp. Neurol. 45, 65-78.[ISI][Medline]
Nakagawa, Y., Perentes, E., and Rubinstein, L.J. (1986) Immunohistochemical characterization of oligodendrogliomas: An analysis of multiple markers. Acta. Neuropathol. 72,15 -22.[CrossRef][Medline]
Nakagawa, Y., Perentes, E., and Rubinstein, L.J. (1987) Non-specificity of anti-carbonic anhydrase C antibody as a marker in human neurooncology. J. Neuropathol. Exp. Neurol. 46,451 -460.[ISI][Medline]
Nakamura, Y., Becker, L.E., and Marks, A. (1983) Distribution of immunoreactive S-100 protein in pediatric brain tumors. J. Neuropathol. Exp. Neurol. 42,136 -145.[ISI][Medline]
Nakopoulou, L., Kerezoudi, E., Thomaides, T., and Litsios, B. (1990) An immunocytochemical comparison of glial fibrillary acidic protein, S-100p and vimentin in human glial tumors. J. Neurooncol. 8,33 -40.[Medline]
Ng, H.K., Ko, H.C.W., and Tse C.C.H (1994) Immunohistochemical and ultrastructural studies of oligodendrogliomas revealed features of neuronal differentiation. Int. J. Surg. Pathol. 2,47 -56.
Nishizaki, T., Ozaki, S., Harada, K., Ito, H., Arai, H., Beppu, T., and Sasaki, K. (1998) Investigation of genetic alterations associated with the grade of Astrocytic Tumor by comparative genomic hybridization. Genes Chromosomes Cancer 21,340 -346.[CrossRef][ISI][Medline]
Ogawa, H., Sato, Y., Takeshita, I., Tateishi, J., and Kitamura, K. (1985) Transient expression of glial fibrillary acidic protein in developing oligodendrocytes in vitro. Brain Res. 350,133 -141.[Medline]
Perentes, E., and Rubinstein, L.J. (1986) Immunohistochemical recognition of human neuroepithelial tumours by anti-Leu 7 (HNK-I) monoclonal antibody. Acta. Neuropathol. 69,227 -233.[CrossRef][Medline]
Raff, M.C., Abney, E.A., and Fok-Seang, J. (1985) Reconsitution of a developmental clock in vitro, a critical role for astrocytes in the timing of oligodendrocyte differentiation. Cell 42,61 -69.[CrossRef][ISI][Medline]
Ransom, D.T., Ritland, S.R., Jenkins, R.B., Scheithauer, B., Kelly, P.J., and Kimmel, D.W. (1991) Loss of heterozygosity studies in human gliomas. Proc. Am. Assoc. Cancer Res. 32, 302. (Abstract)
Reifenberger, J., Reifenberger, G., Liu, L., James, C.D., Wechsler, W., and Collins, V.P. (1994) Molecular genetic analysis of oligodendroglial tumors shows preferential allelic deletions on 19q and 1p. Am. J. Pathol. 145,1175 -1190.[Abstract]
Ritland, S.R., Ganju, V., and Jenkins, R.B. (1995) Region-specific loss of heterozygosity on chromosome 19 is related to the morphologic type of human glioma. Genes Chromosomes Cancer 12,277 -282.[ISI][Medline]
Rosenberg, J.E., Lisle, D.K., Burwick, J.A., Ueki, K., von Deimling, A., Mohrenweiser, H.W., and Louis, D.N. (1996) Refined deletion mapping of the chromosome 19q glioma tumor suppressor gene to the D19S412-STD interval. Oncogene 13, 2483-2485. (Short report)[ISI][Medline]
Rosso, S.M., van Dekken, H., Krishnadath, K.K., Alers, J.C., and Kros, J.M. (1997) Detection of chromosomal changes by interphase cytogenetics in biopsies of recurrent astrocytomas and oligodendrogliomas. J. Neuropathol. Exp. Neurol. 56,1125 -1131.[ISI][Medline]
Schiffer, D., Dutto, A., Cavalla, P., Chio, A., Micheli, A., and Piva, R. (1997) Role of apoptosis in the prognosis of oligodendrogliomas. Neurochem. Int. 31,245 -250.[CrossRef][ISI][Medline]
Shaw, E.G., Scheithauer, B.W., O'Fallon, J.R., Tazelaar, H.D., and Davis, D.H. (1992) Oligodendrogliomas: The Mayo Clinic experience. J. Neurosurg. 76,428 -434.[ISI][Medline]
Shaw, E.G., Scheithauer, B.W., O'Fallon, J.R., and Davis, D.H. (1994) Mixed oligoastrocytomas: A survival and prognostic factor analysis. Neurosurgery 34,577 -582.[ISI][Medline]
Smith, M.T., Ludwig, C.T., Godfrey, A.D., and Ambrustmacher, V.W. (1983) Grading of oligodendrogliomas. Cancer 52,2107 -2114.[CrossRef][ISI][Medline]
von Deimling, A., Louis, D.N., von Ammon, K., Petersen, I.,
Weistler, O.D., and Seizinger, B.R. (1992) Evidence for a tumor
suppressor gene on chromosome 19q associated with human astrocytomas,
oligodendrogliomas, and mixed gliomas. Cancer Res.
52,4277
-4279.
von Deimling, A., Nagel, J., Bender, B., Lenartz, D., Schramm, J., Louis, D.N., and Weistler, O.D. (1994) Deletion mapping of chromosome 19 in human gliomas. Int. J. Cancer 57,676 -680.[ISI][Medline]
Wharton, S.B., Hamilton, F.A., Chan, W.K., Chan, K.K., and Anderson, J.R. (1998) Proliferation and cell death in oligodendrogliomas. Neuropathol. Appl. Neurobiol. 24, 21-28.[ISI][Medline]
Weber, R.G., Sabel, M., Reifenberger, J., Sommer, C., Oberstrab, J., Reifenberger, G., Kiessling, M., and Cremer, T. (1996) Characterization of genomic alterations associated with glioma progression by comparative genomic hybridization. Oncogene 13,983 -994.[ISI][Medline]
Yong, W.H., Chou, D., Ueki, K., Harsh, G.R., von Deimling, A., Gusella, J.F., Mohrenweiser, H.W., and Louis, D.N. (1995) Chromosome 19q deletions in human gliomas overlap to D19S219 and may target a 425 kb region centromeric to D19S112. J. Neuropathol. Exp. Neurol. 54,622 -626.[ISI][Medline]
Zhu, J.J., Santarius, T., Wu, X., Tsong, J., Guha, A., Wu, J.K., Hudson, T.J., and Black, P.M. (1998) Screening for loss of heterozygosity and micorsatellite instability in oligodendrogliomas. Genes Chromosomes Cancer 21,207 -216.[CrossRef][ISI][Medline]
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