QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:
Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text Full Text (PDF) All Versions of this Article: 9/3/343    most recent 15228517-2007-007v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (2) Citing Articles via Google Scholar Google Scholar Articles by Sampson, j. H. Articles by Pedain, C. Search for Related Content PubMed PubMed Citation

Clinical utility of a patient-specific algorithm for simulating intracerebral drug infusions

Department of Surgery, Division of Neurosurgery (J.H.S., A.H.F., D.A.R.), Department of Radiology (J.P., R.E.C., T.W.), Department of Pathology (J.H.S., D.D.B.), and Department of Biostatistics and Bioinformatics (J.E.H.), Duke University Medical Center, Durham, NC 27710, USA; Therataxis, LLC, Baltimore, MD 21210, USA (R.R., M.L.B.); NeoPharm, Inc., Waukegan, IL 60085, USA (D.C.); Laboratory of Molecular Biology, NCI, NIH, Bethesda, MD 20892, USA (I.P.); BrainLAB, 85622 Feldkirchen, Germany (M.I.R.-P., C.P.); Department of Neurosurgery, Klinikum Grosshadern, University of Munich, D-81377 Munich, Germany (P.T.); and Division of Cellular and Gene Therapies, CBER, Food and Drug Administration, Bethesda, MD 20892, USA (R.P.)

Address correspondence to john H. Sampson, Division of Neurosurgery, Department of Surgery, Box 3050, Duke university Medical Center, Durham, NC 27710, USA (john.sampson{at}duke.edu).

Convection-enhanced delivery (CED) is a novel drug delivery technique that uses positive infusion pressure to deliver therapeutic agents directly into the interstitial spaces of the brain. Despite the promise of CED, clinical trials have demonstrated that target-tissue anatomy and patient-specific physiology play a major role in drug distribution using this technique. In this study, we retrospectively tested the ability of a software algorithm using MR diffusion tensor imaging to predict patient-specific drug distributions by CED. A tumor-targeted cytotoxin, cintredekin besudotox (interleukin 13-PE38QQR), was coinfused with iodine 123-labeled human serum albumin (¹²³I-HSA), in patients with recurrent malignant gliomas. The spatial distribution of ¹²³I-HSA was then compared to a drug distribution simulation provided by the software algorithm. The algorithm had a high sensitivity (71.4%) and specificity (100%) for identifying the high proportion (7 of 14) of catheter trajectories that failed to deliver drug into the desired anatomical region (p = 0.021). This usually occurred when catheter trajectories crossed deep sulci, resulting in leak of the infusate into the subarachnoid cerebrospinal fluid space. The mean concordance of the volume of distribution at the 50% isodose level between the actual ¹²³I-HSA distribution and simulation was 65.75% (95% confidence interval [CI], 52.0%-79.5%), and the mean maximal inplane deviation was less than 8.5 mm (95% CI, 4.0-13.0 mm). The use of this simulation algorithm was considered clinically useful in 84.6% of catheters. Routine use of this algorithm, and its further developments, should improve prospective selection of catheter trajectories, and thereby improve the efficacy of drugs delivered by this promising technique.

Key Words: brain neoplasms • computer simulation • convection • drug delivery systems • single-photon emission computed tomography

This article has been cited by other articles:

				T. Martens, Y. Laabs, H. S. Gunther, D. Kemming, Z. Zhu, L. Witte, C. Hagel, M. Westphal, and K. Lamszus Inhibition of Glioblastoma Growth in a Highly Invasive Nude Mouse Model Can Be Achieved by Targeting Epidermal Growth Factor Receptor but not Vascular Endothelial Growth Factor Receptor-2 Clin. Cancer Res., September 1, 2008; 14(17): 5447 - 5458. [Abstract] [Full Text] [PDF]

				J. H. Sampson, G. Akabani, G. E. Archer, M. S. Berger, R. E. Coleman, A. H. Friedman, H. S. Friedman, K. Greer, J. E. Herndon II, S. Kunwar, et al. Intracerebral infusion of an EGFR-targeted toxin in recurrent malignant brain tumors Neuro-oncol, January 1, 2008; 10(3): 320 - 329. [Abstract] [Full Text] [PDF]