QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:
Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Allen, J. C. Articles by Biegel, J. A. Search for Related Content PubMed PubMed Citation

Atypical teratoid/rhabdoid tumor evolving from an optic pathway ganglioglioma: Case study¹

Department of Neurology, New York University School of Medicine, New York, NY 10016 (J.C.A.); Departments of Pathology (A.R.J., J.A.B.) and Pediatrics (J.A.B.), The Children's Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, PA 19104; Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY, 10021(M.K.R.); USA

² Address correspondence to Jaclyn Biegel, Room 1002, Abramson Research Center, The Children's Hospital of Philadelphia, 3615 Civic Center Boulevard, Philadelphia, PA 19104, USA (biegel{at}mail.med.upenn.edu).

We report an atypical teratoid/rhabdoid tumor arising in a ganglioglioma from an 11-year-old male who had been treated over a nine-year period. A combined histologic, immunohistochemical, and molecular genetic analysis confirmed this diagnosis. Molecular genetic studies demonstrated a mutation in exon 9 of the INI1 gene in the tumor, which was not present in the patient's blood. This report is the first to describe progression of a ganglioglioma to atypical teratoid/rhabdoid tumor.

Key Words: atypical teratoid tumor • ganglioglioma • hSNF5/INI1 • rhabdoid tumor

This article has been cited by other articles:

				S. Gururangan, M. J. Fisher, J. C. Allen, J. E. Herndon II, J. A. Quinn, D. A. Reardon, J. J. Vredenburgh, A. Desjardins, P. C. Phillips, M. A. Watral, et al. Temozolomide in Children with progressive low-grade glioma Neuro-oncol, April 1, 2007; 9(2): 161 - 168. [Abstract] [Full Text] [PDF]