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Cerebral edema associated with Gliadel wafers: Two case studies

Tri-State Neurosurgical, Inc., Evansville, IN 47710, USA

¹ Address correspondence to Eric Goebel, Tri-State Neurosurgical, Inc., 350 West Columbia Street, Suite 350, Evansville, IN 47710, USA (egoebel{at}iupui.edu).

Abstract

While the introduction of carmustine wafers (Gliadel wafers) into the tumor resection cavity has been shown to be a beneficial therapy for malignant glioma, it is recognized that clinically significant cerebral edema is a potential adverse effect. Following are two clinical case reports demonstrating profound cerebral edema associated with implantation of Gliadel wafers. As a result, one of these individuals had premature death. A brief literature review is provided to assist in explaining the mechanisms by which clinically significant cerebral edema may develop.

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