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Transmission of glioblastoma multiforme following bilateral lung transplantation from an affected donor: Case study and review of the literature

Department of Oncology (M.Y.A., S.A.G.); Department of Surgery, Division of Thoracic Surgery (S.C.Y.); Department of Pathology (P.C.B.); and Department of Medicine, Division of Pulmonary and Critical Care (J.B.O.), Johns Hopkins Medical Institutions, Baltimore, MD 21231; University of Maryland School of Medicine, Baltimore, MD 21201 (B.W.); and Washington University School of Medicine, St. Louis, MO 63110 (A.P.); USA

¹ Address correspondence to Mary Y. Armanios, Department of Oncology, Johns Hopkins Medical Institutions, 1650 Orleans Street, Cancer Research Building, Room 86, Baltimore, MD 21231 (marmani1{at}jhmi.edu).

Abstract

Donor-acquired solid organ malignancy is a rare complication of organ transplantation. We report a case of a patient who received bilateral lung transplants for pulmonary fibrosis from a donor with known glioblastoma multiforme (GBM). The lungs, heart, liver, and kidneys were harvested after a lethal intracranial bleed and accepted for transplantation by four centers. An enlarged hilar lymph node sampled at the time of transplant was found to contain GBM. Four months later, the patient developed diffuse interstitial pulmonary infiltrates with mediastinal lymphadenopathy. Lung biopsy confirmed metastatic GBM. The patient died 2 weeks after the diagnosis was established. The patient receiving the donor liver also developed GBM. We present a case study, review of the literature, and suggested interventions to minimize the risk of transmission.

This article has been cited by other articles:

				H. Chen, A. S. Shah, R. E. Girgis, and S. A. Grossman Transmission of Glioblastoma Multiforme After Bilateral Lung Transplantation J. Clin. Oncol., July 1, 2008; 26(19): 3284 - 3285. [Full Text] [PDF]