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Does brain tumor histology influence cognitive function?

The University of Texas M.D. Anderson Cancer Center, Department of Neuro-Oncology, Houston, TX 77030

¹ Address correspondence to Anne E. Kayl, University of Texas M.D. Anderson Cancer Center, Department of Neuro-Oncology (431), 1515 Holcombe Blvd., Houston, TX 77030 (akayl{at}mail.mdanderson.org).

Abstract

This retrospective study investigated the relationship between tumor histology and postsurgical cognitive function in patients diagnosed with malignant brain tumors. The neuropsychological functioning of 24 adult patients diagnosed with glioblastoma multiforme (GBM) was compared with the neuropsychological functioning of 24 adult patients diagnosed with anaplastic astrocytoma (AA). The groups were matched with respect to patient age, gender, and education, as well as tumor location and tumor volume. The mean raw test scores of the AA patient group were superior to the mean scores of the GBM patient group on nearly all measures administered. However, significant performance differences were not detected for any of 5 neuropsychological domain scores (Intellectual, Language, Memory, Executive, and Motor Function). Analysis of covariance (ANCOVA) revealed that tumor histology was not a significant predictor of domain score after controlling for tumor volume. Multiple regression and correlation analyses supported the results of the ANCOVA by offering further evidence of weak relationships between tumor type, tumor volume, and neuropsychological test scores. We conclude that tumor histology is not clearly predictive of cognitive performance in adults with AA and GBM.

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