|
|
|
|
|
|
||
|
|
||||
|
|
||||
|
||||
Neuropathology |
Departments of Neurosurgery (L.E., M.N.P.), Neuropathology (Ö.K.-Y., A.S.), and Radiology (G.E.), Marmara University School of Medicine, Istanbul, Turkey; Department of Anatomy, Universitario de Santiago de Compostela, Lugo, Spain (S.V.); Department of Laboratory Medicine, St. Michael's Hospital, Toronto, Ontario, Canada (K.K.); and the Department of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, MN 55905 (B.W.S.)
1 Address correspondence and reprint requests to B. W. Scheithauer, Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 1st St. SW, Rochester, MN 55905.
Abstract
We report a case of suprasellar papillary craniopharyngioma metastatic to the temporoparietal region 2 years after its initial resection. The literature documents examples of craniopharyngioma recurrences along the surgical tract, as well as remote ipsi- and contralateral metastases via cerebrospinal fluid seeding. Ours is the second report of a craniopharyngioma of papillary type to exhibit metastatic behavior. The tumor spread opposite the side of craniotomy. Although a rare occurrence, it confirms the limited capacity of histologically benign craniopharyngiomas to undergo meningeal seeding, likely the result of surgical manipulation. Immunohistochemical demonstration of increased microvascular density and vascular endothelial growth factor expression, as well as a high vascular endothelial growth receptor (VEGFR2) signal by in situ hybridization, suggests that tumor vascularity facilitated angiogenesis and may have been involved in the establishment and growth of the metastatic deposit.
|
|
