© Copyright 2008 by the Society for Neuro-Oncology
Received July 21, 2008
Accepted October 22, 2008
Basic and Translational Investigations
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Age-incidence patterns of primary CNS tumors in children, adolescents, and adults in England
Ramandeep S. Arora 1*,
Robert D. Alston 2,
Tim O.B. Eden 3,
Edward J. Estlin 2,
Anthony Moran 4,
Jillian M. Birch 2
1 PCancer Research UK Pediatric and Familial Cancer Research Group, Royal Manchester Children's Hospital, Stancliffe, Hospital Road, Manchester M27 4HA, UK
2 Pediatric and Familial Cancer Research Group, Royal Manchester Children's Hospital, Manchester, UK
3 Teenage and Young Adult Cancer, University of Manchester and Teenage Cancer Trust Young Oncology Unit, Christie Hospital, NHS Foundation Trust, Manchester, UK
4 North West Cancer Intelligence Service, Christie Hospital, NHS Foundation Trust, Manchester, UK
* To whom correspondence should be addressed. E-mail: reemaraman{at}doctors.org.uk.
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Abstract |
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Around 25% of all tumors in those aged 0–14 years and 9% in those aged 15 to 24 years involve the central nervous system (CNS). They are the most common cause of cancer-related deaths in this age. In adults aged 25–84 years the proportion of CNS tumors is 2%. 5 year overall survival is 10–15% and there is considerable morbidity in survivors. Comprehensive up to date population-based incidence data on these tumors are lacking. We present incidence rates for primary CNS tumors based on data that have been derived from the high quality national cancer registration system in England. 54,336 CNS tumors of malignant, benign and uncertain behaviour were registered across the whole of England from 1995 to 2003. The age standardized rates for all ages (0 to 84 years) was 9.21 per 100,000 person years. This is higher than previously reported for England since it includes non-malignant CNS tumors and hence gives a more accurate picture of burden of disease. The age standardized rates for those aged 0 to 14 years, 15 to 24 years and 25 to 84 years were 3.56, 3.26 and 14.57 per 100,000 person years respectively. We describe the changing patterns in the epidemiology of primary CNS tumors in these three age groups with respect to sex, behaviour and histology using the current WHO classification. This will provide a reference for future studies nationally and internationally and make comparisons relevant and meaningful.
Key Words:
cancer registry, central nervous system, England, epidemiology, tumor incidence, WHO Classification
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