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Clinical Investigations |
Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen (M.S.N., H.C.C., C.J.) and Department of Neurosurgery, University Hospital of Copenhagen, Copenhagen (M.K.); Denmark
Address correspondence to Christoffer Johansen, Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, DK-2100 Copenhagen, Denmark (christof{at}cancer.dk).
We established the nationwide, population-based incidence of oligodendroglioma in Denmark during 59 years of monitoring and compared the overall survival of patients with oligodendroglial tumors during the periods 1943–1977 and 1978–2002. On the basis of reports in the Danish Cancer Registry, 1,304 cases of oligodendroglioma were included in the study. We calculated sex- and age-specific incidence rates in 5-year age intervals and for 5-year calendar periods. Overall survival was estimated by the Kaplan-Meier method. In the period 1943–2002, the incidence rate of oligodendroglioma was less than 1 case per 100,000 person-years, but varied somewhat when viewed across isolated periods. Comparison of the incidence rate before and after the introduction of CT scanning did not reveal a significant difference in the incidence rate. The median survival increased from 1.4 years (95% confidence interval [CI], 1.0–1.6) to 3.4 years (95% CI, 2.6–4.2) during the period of study. The overall incidence of oligodendroglioma showed a relatively stable pattern over nearly 60 years of monitoring. Overall survival improved significantly during the study period, which could partly be due to improved diagnostic methods and treatment options.
Key Words: Denmark • epidemiology • oligodendroglioma
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