QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:
Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Comas, T. C. Articles by Yates, A. J. Search for Related Content PubMed PubMed Citation Social Bookmarking                   What's this?

Immunohistochemical staining for ganglioside GD1b as a diagnostic and prognostic marker for primary human brain tumors

The Ohio State University, Columbus, OH 43210 (T.C.C., D.K.P., S.D.J., A.J.Y.); Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan (T.T.); Mayo Foundation, Rochester, MN 55905 (D.K., B.W.S.); and Johns Hopkins University, Baltimore, MD 21287 (P.C.B.)

² Address correspondence and reprint requests to Allan J. Yates, M.D., Ph.D., Professor and Head, Division of Neuropathology, Room 4168 Graves Hall, 333 West 10th Ave., Columbus, OH 43210.

Abstract

Immunohistochemical staining intensity for ganglioside GD1b was determined for 108 human neuroectodermal tumors. Most of the tissue elements that immunostained were tumor cells; only a few axons and occasional neurons reacted in some specimens. All pilocytic astrocytomas stained very positively, whereas none of the ependymomas and only 11% of primitive neuroectodermal tumors, 20% of glioblastomas, and 28% of anaplastic astrocytomas showed more than faint staining. A similar association between grade and immunostaining was seen in tumors containing an oligodendrogliomatous component, but reactivity was not as strong as in astrocytic tumors or primitive neuroectodermal tumors. Results of Cox regression showed significant associations between immunostaining intensity and survival for all cases taken together (P = 0.007); for the group consisting of astrocytomas, oligoastrocytomas, and oligodendrogliomas (P = 0.002); and for astrocytomas alone (P = 0.04). Results were also significant using a proportional hazards model controlling for patient age (all cases P = 0.005; astrocytomas only P = 0.02), but not when controlling for tumor grade. Our results indicate that immunohistochemical staining for GD1b is correlated with tumor grade and that it may be of prognostic utility in some primary human brain tumors, especially astrocytomas.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				S. Hettmer, C. Malott, W. Woods, S. Ladisch, and K. Kaucic Biological Stratification of Human Neuroblastoma by Complex "B" Pathway Ganglioside Expression Cancer Res., November 1, 2003; 63(21): 7270 - 7276. [Abstract] [Full Text] [PDF]